FB2026_02 , released June 18, 2026
Allele: Dmel\cmpyUAS.cJa
Open Close
General Information
Symbol
Dmel\cmpyUAS.cJa
Species
D. melanogaster
Name
FlyBase ID
FBal0261240
Feature type
allele
Associated gene
Dmel\cmpy
Associated Insertion(s)
Carried in Construct
P{UAS-cmpy.J}
Also Known As
UAS-cmpy
Key Links
Transgenic product class
wild_type
(James and Broihier, 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(James and Broihier, 2011)
Mutagen
in vitro construct
(James and Broihier, 2011)
Progenitor genotype
Carried in construct
P{UAS-cmpy.J}
Cytology
Description

UAS regulatory sequences drive expression of cmpy.

(James and Broihier, 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
cmpy
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of cmpyScer\UAS.cJa using Scer\GAL4elav.PU or Scer\GAL4D42 in an otherwise wild type background does not alter neuromuscular junction growth.

      Overexpression of cmpyScer\UAS.cJa using Scer\GAL4how-24B results in a 20% decrease in type 1 boutons at neuromuscular junction NMJ) 6/7 and a 22% decrease at NMJ 4. .

      (James and Broihier, 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of cmpyScer\UAS.cJa suppresses the neuromuscular overgrowth phenotype caused by expression of gbbScer\UAS.cKa using either Scer\GAL4D42 or Scer\GAL4OK6.

      Co-expression of cmpyScer\UAS.cJa suppresses the wing blistering phenotype caused by Scer\GAL4A9-mediated expression of gbbScer\UAS.cKa in males and females.

      (James and Broihier, 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      cmpyUAS.cJa/Scer\GAL4Toll-6-D42 rescues cmpyΔ8

      (James et al., 2014)
      Partially rescues

      cmpyUAS.cJa/Scer\GAL4elav.PU partially rescues cmpyΔ8

      (James and Broihier, 2011)

      cmpyUAS.cJa/Scer\GAL4Toll-6-D42 partially rescues cmpyΔ8

      (James and Broihier, 2011)
      Comments

      Expression of cmpyScer\UAS.cJa under the control of Scer\GAL4Toll-6-D42 rescues the reduction in evoked excitatory junction potential amplitude and in quantal content which is seen at the neuromuscular junction in homozygous cmpyΔ8 larvae.

      (James et al., 2014)

      Scer\GAL4D42-mediated overexpression of cmpyScer\UAS.cJa in a cmpyΔ8 background fully rescues bouton number at neuromuscular junction (NMJ) 4 whereas overgrowth is reduced from 52% to 9% at NMJ 6/7. Comparable rescue is observed when Scer\GAL4elav.PU is used.

      (James and Broihier, 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      cmpyScer\UAS.cJa
      cmpyUAS.cJa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)