FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Prosβ5HMS00119
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General Information
Symbol
Dmel\Prosβ5HMS00119
Species
D. melanogaster
Name
FlyBase ID
FBal0263124
Feature type
allele
Associated gene
Dmel\Prosβ5
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS00119}
Also Known As
UAS-Prosβ5 RNAi, Prosβ5 RNAi, HMS00119
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
in vitro construct
(Ni et al., 2011.7.19)
Progenitor genotype
Carried in construct
P{TRiP.HMS00119}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMS00119
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  neurodegenerative disease
      CEA
      (Fernández-Cruz et al., 2020)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing Prosβ5HMS00119 under the control of Scer\GAL4VP16.mat.αTub67C induces a thicker F-actin rim in egg chamber ring canals.

      (Hudson et al., 2019)

      Expressing Prosβ5HMS00119 under the control of Scer\GAL4Cg.PA leads to fuzzy and clustered mitochondria in the third instar larval fat body (as assessed by MitoGFP).

      (Zhou et al., 2019)

      The expression of Prosβ5HMS00119 under the control of Scer\GAL4Gli.PU leads to occasional bulging of peripheral nerves associated to an increase in the number of subperineurial glial cell nuclei, as compared to controls.

      (Zülbahar et al., 2018)

      Expression of Prosβ5HMS00119 RNAi under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 results in egg chamber growth arrest and eventual degeneration and before then display dramatic thickening of the F-actin cytoskeleton, kel protein accumulation and decreased lumen diameter in the nurse cell ring canals compared to controls.

      (Hudson et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The nurse cell ring canal phenotype (thickening of the F-actin cytoskeleton, smaller lumen diameter) observed in female flies expressing Prosβ5HMS00119 under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 is significantly enhanced by combination with kelDE1 in heterozygous state.

      (Hudson et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Prosβ5HMS00119
      Name Synonyms
      Secondary FlyBase IDs
        References (19)