FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dawHMS01110
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General Information
Symbol
Dmel\dawHMS01110
Species
D. melanogaster
Name
FlyBase ID
FBal0263231
Feature type
allele
Associated gene
Dmel\daw
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS01110}
Also Known As
UAS-Daw RNAi, HMS01110
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
in vitro construct
(Ni et al., 2011.7.19)
Progenitor genotype
Carried in construct
P{TRiP.HMS01110}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMS01110
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of dawHMS01110 under the control of Scer\GAL4NP1624 during adulthood (under the additional control of Gal80{ts]) induces a progressive decrease in the number of hub cells in the testes.

      (Herrera et al., 2021)

      Adults with Scer\GAL4αTub84B.Switch.PK or Scer\GAL4da.Switch.PT and dawHMS01110, fed with RU486 to activate expression, show extended lifespan compared to controls.

      Scer\GAL4Mhc.PW dawHMS01110 adults, but not Scer\GAL4Switch1.106 dawHMS01110 adults, show extended lifespan compared to controls.

      Scer\GAL4Mhc.PW-mediated expression of dawHMS01110 retards the normal decline in flight activity seen in aging flies, and delays the normal increase in protein aggregates and the normal decrease in lysosomes/autophagic vacuoles within muscle.

      Scer\GAL4Mhc.PW-mediated expression of dawHMS01110 reduces the level of circulating Ilp2 protein in the hemolymph.

      Scer\GAL4Mhc.PW-mediated expression of dawHMS01110 does not affect female fecundity.

      (Bai et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Scer\GAL4Mhc.PW, dawHMS01110 has long lived phenotype, suppressible by Atg8aHMS01328, Scer\GAL4Mhc.PW

      (Bai et al., 2013)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Atg8aHMS01328 blocks the longevity induced by Scer\GAL4Mhc.PW-mediated expression of dawHMS01110.

      (Bai et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      dawHMS01110
      Name Synonyms
      Secondary FlyBase IDs
        References (10)