FlyBase Allele Report: Dmel\mud[HMS01458]

General Information

Symbol

Dmel\mud^HMS01458

Species

D. melanogaster

Name

FlyBase ID

FBal0263366

Feature type

allele

Associated gene

Dmel\mud

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01458}

Also Known As

UAS-mud-RNAi, mud RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS01458}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01458

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA with Ras85D^V12.UAS

(Muzzopappa et al., 2017)

CEA with BacA\p35^UAS.cHa

(Muzzopappa et al., 2017)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^hh.PU, mud^HMS01458 has neoplasia | larval stage phenotype, suppressible by wg^GD5007, Scer\GAL4^hh.PU

(Muzzopappa et al., 2017)

BacA\p35^UAS.cHa, Scer\GAL4^en-e16E, mud^HMS01458 has neoplasia | larval stage phenotype, suppressible by wg^GD5007/Scer\GAL4^hh.PU

(Muzzopappa et al., 2017)

NOT Enhancer of

Statement

Reference

mud^HMS01458, Scer\GAL4^GMR.PU is a non-enhancer of visible | adult stage | progressive phenotype of Chchd2^S81L.UAS, Scer\GAL4^GMR.PU

(Baek et al., 2021)

NOT Suppressor of

Statement

Reference

mud^HMS01458, Scer\GAL4^GMR.PU is a non-suppressor of visible | adult stage | progressive phenotype of Chchd2^S81L.UAS, Scer\GAL4^GMR.PU

(Baek et al., 2021)

Other

Statement

Reference

BacA\p35^UAS.cHa, Scer\GAL4^en-e16E, mud^HMS01458 has abnormal developmental rate | larval stage phenotype

(Muzzopappa et al., 2017)

BacA\p35^UAS.cHa, Scer\GAL4^en-e16E, mud^HMS01458 has increased body size | pupal stage phenotype

(Muzzopappa et al., 2017)

BacA\p35^UAS.cHa, Scer\GAL4^en-e16E, mud^HMS01458 has increased body size | larval stage phenotype

(Muzzopappa et al., 2017)

BacA\p35^UAS.cHa, Scer\GAL4^en-e16E, mud^HMS01458 has neoplasia | larval stage phenotype

(Muzzopappa et al., 2017)

BacA\p35^UAS.cHa, Scer\GAL4^en-e16E, mud^HMS01458 has increased occurrence of cell division | larval stage phenotype

(Muzzopappa et al., 2017)

Ras85D^V12.UAS, Scer\GAL4^hh.PU, mud^HMS01458 has neoplasia | larval stage phenotype

(Muzzopappa et al., 2017)

Phenotype Manifest In

Suppressed by

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^hh.PU, mud^HMS01458 has wing disc phenotype, suppressible by wg^GD5007, Scer\GAL4^hh.PU

(Muzzopappa et al., 2017)

BacA\p35^UAS.cHa, Scer\GAL4^en-e16E, mud^HMS01458 has wing disc phenotype, suppressible by wg^GD5007/Scer\GAL4^hh.PU

(Muzzopappa et al., 2017)

NOT Enhancer of

Statement

Reference

mud^HMS01458, Scer\GAL4^GMR.PU is a non-enhancer of eye phenotype of Chchd2^S81L.UAS, Scer\GAL4^GMR.PU

(Baek et al., 2021)

NOT Suppressor of

Statement

Reference

mud^HMS01458, Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of Chchd2^S81L.UAS, Scer\GAL4^GMR.PU

(Baek et al., 2021)

Other

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^hh.PU, mud^HMS01458 has wing disc phenotype

(Muzzopappa et al., 2017)

BacA\p35^UAS.cHa, Scer\GAL4^en-e16E, mud^HMS01458 has wing disc phenotype

(Muzzopappa et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The co-expression of mud^HMS01458 and BacA\p35^UAS.cHa under the control of Scer\GAL4^hh.PU induces wing disc malignant tumors that show increased mitotic index and are able to grow in allograft transplantations.

The co-expression of Ras85D^V12.UAS and mud^HMS01458 under the control of Scer\GAL4^hh.PU induces wing disc tumor-like growths.

(Muzzopappa et al., 2017)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

35044

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01458}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

mud^HMS01458

mud^RNAi

(Parra et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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