FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CanA1KO
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General Information
Symbol
Dmel\CanA1KO
Species
D. melanogaster
Name
FlyBase ID
FBal0263891
Feature type
allele
Associated gene
Dmel\CanA1
Associated Insertion(s)
TI{TI}CanA1KO
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ends-out gene targeting
(Nakai et al., 2011)
I-SceI
(Nakai et al., 2011)
FLPase
(Nakai et al., 2011)
Progenitor genotype
Associated Insertion(s)
TI{TI}CanA1KO
Cytology
Description

Exons 2 and 3 of CanA1 have been replaced by loxP cassette containing a wGMR.PH marker. An attP site is present downstream of the 3 'loxP site to allow future integration of constructs into the knock-out site.

(Nakai et al., 2011)
Allele components
Component
Use(s)
Also carries
attP
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      CanA1KO mutants exhibit a decrease in total daily activity and an increase in total sleep, both in LD and DD conditions.

      (Nakai et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CanA1KO
      (Nakai et al., 2011)
      Df-canA1
      (Wong et al., 2014)
      canA1KO2-2
      (Wong et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)