FlyBase Allele Report: Dmel\Uvrag[B7]

General Information

Symbol

Dmel\Uvrag^B7

Species

D. melanogaster

Name

FlyBase ID

FBal0264045

Feature type

allele

Associated gene

Dmel\Uvrag

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Lee et al., 2011)

Mutagen

P-element activity

(Lee et al., 2011)

Progenitor genotype

P{SUPor-P}Uvrag^KG04163

(Lee et al., 2011)

Cytology

Description

Imprecise excision of P{SUPor-P}Uvrag^KG04163 that deletes the first exon and part of the second exon of Uvrag.

(Lee et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage (with Df(2L)ED784)

(Lee et al., 2011)

lethal - all die before end of larval stage | male limited

(Takáts et al., 2014)

lethal - all die before end of larval stage | recessive

(Lee et al., 2011)

lethal - all die before end of P-stage | recessive

(Takáts et al., 2014)

some die during larval stage (with Df(2L)ED784)

(Lee et al., 2011)

some die during larval stage | recessive

(Lee et al., 2011)

Phenotype Manifest In

male genitalia (with Uvrag^KG04163)

(Lee et al., 2011)

Detailed Description

Statement

Reference

~75% of Uvrag^KG04163/Uvrag^B7 or Uvrag^KG04163/Uvrag^B21 males show incomplete genitalia rotation, though the direction of rotation is wild type.

(Lee et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Expression of Uvrag^{Scer\UAS.T:Zzzz\FLAG} using Scer\GAL4^Abd-B-LDN, but not Scer\GAL4^elav.PU or Scer\GAL4^Lsp2.PH, rescues the genital rotation defect of Uvrag^KG04163/Uvrag^B21 males.

Heat-shock induced expression of Uvrag^{Scer\UAS.T:Zzzz\FLAG} using Scer\GAL4^hs.PU, induced by a heat shock on day 7 +/- 2 days (late larval to early pupal stages), is sufficient to rescue the genital rotation defect of Uvrag^KG04163/Uvrag^B21 males.

(Lee et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

UVRAG^B7

(Lee et al., 2011)

UVRAG[B7]

(Takáts et al., 2014)

Uvrag^B7

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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