FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\DarkE4
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General Information
Symbol
Dmel\DarkE4
Species
D. melanogaster
Name
FlyBase ID
FBal0264389
Feature type
allele
Associated gene
Dmel\Dark
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Srivastava et al., 2007)
Mutagen
ethyl methanesulfonate
(Srivastava et al., 2007)
Progenitor genotype
Cytology
Description

Amino acid replacement: S1024F.

(Srivastava et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:17,024,990..17,024,990 [+]
Nucleotide change:

C17024990T

Amino acid change:

S1024F | Dark-PB

Reported amino acid change:

S1024F

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Srivastava et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ArkE4 mutants show a significant reduction in embryonic cell death.

      Stage 17 ArkE4 embryos contain on average 9.1 midline glia cells per segment, compared to 3 such cells in wild type.

      (Srivastava et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      DarkE4 is a suppressor of eye phenotype of hidGMR.PG

      (Srivastava et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The WGMR.PG eye ablation phenotype is strongly suppressed when eyes carry homozygous clones for ArkE4.

      (Srivastava et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      ArkE4
      DarkE4
      E4
      (Srivastava et al., 2007)
      arkE4
      (Srivastava et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)