FlyBase Allele Report: Dmel\p38b[Δ45]

General Information

Symbol

Dmel\p38b^Δ45

Species

D. melanogaster

Name

FlyBase ID

FBal0264804

Feature type

allele

Associated gene

Dmel\p38b

Associated Insertion(s)

Carried in Construct

Also Known As

p38Kb^Δ45

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Schoborg et al., 2013)

Mutagen

P-element activity

(Vrailas-Mortimer et al., 2011)

Progenitor genotype

p38b^KG01337

(Vrailas-Mortimer et al., 2011)

Cytology

Description

Excision of P{SUPor-P}p38b^KG01337 results in the removal of 1065bp which includes most of the p38b coding region.

(Vrailas-Mortimer et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2L:13,780,612..13,781,676 [+]

Comment:

Estimated boundaries of a 1065bp deletion resulting from the excision of P{SUPor-P}p38b^KG01337 that removes most of the p38b coding region.

(Vrailas-Mortimer et al., 2011)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal circadian rhythm | progressive

(Vrailas-Mortimer et al., 2014)

abnormal heat stress response

(Vrailas-Mortimer et al., 2011)

abnormal locomotor behavior

(Vrailas-Mortimer et al., 2011)

abnormal neuroanatomy | larval stage

(Klinedinst et al., 2013)

abnormal oxidative stress response

(Vrailas-Mortimer et al., 2011)

short lived | recessive

(Vrailas-Mortimer et al., 2011)

viable

(Vrailas-Mortimer et al., 2011)

Phenotype Manifest In

NMJ bouton | larval stage

(Klinedinst et al., 2013)

Detailed Description

Statement

Reference

p38b^Δ45 homozygous mutants do not display defects in locomotor behaviour.

Young p38b^Δ45 mutants do not display defects in circadian behaviour.

Aged p38b^Δ45 mutants display increased arrhythmicity and a modest but significant increase in tau of 24.9h compared with controls.

(Vrailas-Mortimer et al., 2014)

Mutant larvae show an increase in maximum bouton diameter at the neuromuscular junction compared to controls. Mutant larvae show a mild defect in axonal transport.

The ability of injured axons to sprout after injury is normal in mutant larvae.

(Klinedinst et al., 2013)

Homozygous p38b^Δ45 mutants have significantly reduced lifespans compared to controls, although no change in lifespan is seen in heterozygotes. 3 day old p38b^Δ45 females occasionally exhibit aberrant walking behaviour and 1-2 day old flies are significantly more sensitive to heat shock and hydrogen peroxide-induced oxidative stress compared to controls.

(Vrailas-Mortimer et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

p38b^Δ45 has short lived phenotype, suppressible by Sod2^UAS.cMa/Scer\GAL4^Mef2.PR

(Vrailas-Mortimer et al., 2011)

Other

Statement

Reference

Df(3L)ED229/+, p38b^Δ45 has abnormal neuroanatomy | dominant | larval stage phenotype

(Klinedinst et al., 2013)

p38a¹, p38b^Δ45 has lethal phenotype

(Vrailas-Mortimer et al., 2011)

Sod2ⁿ²⁸³/Sod2[+], p38b^Δ45 has short lived | dominant phenotype

(Vrailas-Mortimer et al., 2011)

Phenotype Manifest In

Other

Statement

Reference

Df(3L)ED229/+, p38b^Δ45 has NMJ bouton | larval stage phenotype

(Klinedinst et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

p38b^Δ45/+ ; Df(3L)ED229/+ double heterozygous larvae show an increase in maximum bouton diameter at the larval neuromuscular junction compared to controls.

(Klinedinst et al., 2013)

Expression of Sod2^Scer\UAS.cMa under the control of Scer\GAL4^Mef2.PR significantly rescues the abbreviated lifespan seen in p38b^Δ45 mutants.

Transheterozygous Sod2ⁿ²⁸³ p38b^Δ45 mutants have significantly reduced lifespans compared to controls.

(Vrailas-Mortimer et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

p38Kb^Δ45

(Ryan et al., 2021, Vrailas-Mortimer et al., 2014, Vrailas-Mortimer et al., 2011)

p38b^Δ45

(Nandi et al., 2017, Dusik et al., 2014, Klinedinst et al., 2013, Schoborg et al., 2013, Vrailas-Mortimer et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (8)

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