Open Close
General Information
Symbol
Dmel\p38bΔ45
Species
D. melanogaster
Name
FlyBase ID
FBal0264804
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
p38KbΔ45
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Excision of P{SUPor-P}p38bKG01337 results in the removal of 1065bp which includes most of the p38b coding region.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

p38bΔ45 homozygous mutants do not display defects in locomotor behaviour.

Young p38bΔ45 mutants do not display defects in circadian behaviour.

Aged p38bΔ45 mutants display increased arrhythmicity and a modest but significant increase in tau of 24.9h compared with controls.

Mutant larvae show an increase in maximum bouton diameter at the neuromuscular junction compared to controls. Mutant larvae show a mild defect in axonal transport.

The ability of injured axons to sprout after injury is normal in mutant larvae.

Homozygous p38bΔ45 mutants have significantly reduced lifespans compared to controls, although no change in lifespan is seen in heterozygotes. 3 day old p38bΔ45 females occasionally exhibit aberrant walking behaviour and 1-2 day old flies are significantly more sensitive to heat shock and hydrogen peroxide-induced oxidative stress compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

p38bΔ45/+ ; Df(3L)ED229/+ double heterozygous larvae show an increase in maximum bouton diameter at the larval neuromuscular junction compared to controls.

Expression of Sod2Scer\UAS.cMa under the control of Scer\GAL4Mef2.PR significantly rescues the abbreviated lifespan seen in p38bΔ45 mutants.

Transheterozygous Sod2n283 p38bΔ45 mutants have significantly reduced lifespans compared to controls.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (6)