FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nak2
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General Information
Symbol
Dmel\Nak2
Species
D. melanogaster
Name
FlyBase ID
FBal0264901
Feature type
allele
Associated gene
Dmel\Nak
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Yang et al., 2011)
Mutagen
P-element activity
(Yang et al., 2011)
Progenitor genotype
P{wHy}NakDG17205
(Yang et al., 2011)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 6.2kb deletion that extends downstream of the original insertion site, removing exon 2-7 of Nak (including the kinase domain).

(Yang et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The complexity of the dendrites of dorsal dendritic arborisation (da) neurons is strongly compromised in mutant larvae; although lower order dendrites remain properly projected, higher-order dendrites are absent or shortened, and some of the shortened dendrites appear clustered.

      Homozygous ddaC neuron single cell clones show shortening and reduction of dendritic branches, with dendrites in medial and distal regions being affected.

      (Yang et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Nak2 is rescued by Scer\GAL4elav-C155/NakUAS.cCa

      (Yang et al., 2011)
      Comments

      Expression of NakScer\UAS.cCa under the control of Scer\GAL4elav-C155 rescues the dendritic defects seen in the dorsal dendritic arborisation neurons of Nak2 larvae.

      (Yang et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Nak2
      nak2
      (Yang et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)