FlyBase Allele Report: Dmel\Nrg[Y1185D.UAS]

General Information

Symbol

Dmel\Nrg^Y1185D.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0264907

Feature type

allele

Associated gene

Dmel\Nrg

Associated Insertion(s)

Carried in Construct

P{UAS-Nrg.Y1185D}

Key Links

Transgenic product class

missense_variant

(Yang et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Yang et al., 2011)

Mutagen

in vitro construct

(Yang et al., 2011)

Progenitor genotype

Carried in construct

P{UAS-Nrg.Y1185D}

Cytology

Description

UAS regulatory sequences drive expression of a mutated form of Nrg, which contains the amino acid replacement Y1185D.

(Yang et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Nrg

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

(Yang et al., 2011)

Phenotype Manifest In

dendrite | larval stage, with Scer\GAL4^elav-C155

(Yang et al., 2011)

dendritic arborizing neuron | larval stage, with Scer\GAL4^elav-C155

(Yang et al., 2011)

Detailed Description

Statement

Reference

The number of dendritic endpoints of dorsal dendritic arborisation neurons is reduced compared to controls in larvae expressing Nrg^{Y1185D.Scer\UAS} under the control of Scer\GAL4^elav-C155.

(Yang et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Nrg^Y1185D.UAS, Scer\GAL4^elav-C155 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Nak^UAS.cCa, Scer\GAL4^elav-C155

(Yang et al., 2011)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Nrg^Y1185D.UAS, Scer\GAL4^elav-C155 has dendritic arborizing neuron | larval stage phenotype, non-suppressible by Nak^UAS.cCa, Scer\GAL4^elav-C155

(Yang et al., 2011)

Nrg^Y1185D.UAS, Scer\GAL4^elav-C155 has dendrite | larval stage phenotype, non-suppressible by Nak^UAS.cCa, Scer\GAL4^elav-C155

(Yang et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Nak^Scer\UAS.cCa does not suppress the reduction in the number of dendritic endpoints of dorsal dendritic arborisation neurons which is seen in larvae expressing Nrg^{Y1185D.Scer\UAS} under the control of Scer\GAL4^elav-C155.

(Yang et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Nrg^{Y1185D.Scer\UAS}

Nrg^Y1185D.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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