FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ebiW418X
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General Information
Symbol
Dmel\ebiW418X
Species
D. melanogaster
Name
FlyBase ID
FBal0265168
Feature type
allele
Associated gene
Dmel\ebi
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide substitution: G?A.

    (Marygold et al., 2011)

    Amino acid replacement: W418term.

    (Marygold et al., 2011)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2L:416,707..416,707 [+]
    Nucleotide change:

    G416707A

    Reported nucleotide change:

    G?A

    Amino acid change:

    W418term | ebi-PA

    Reported amino acid change:

    W418term

    Comment:

    TGG to TGA mutation in codon 418.

    (Marygold et al., 2011)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        ebiP7/ebiW418X wings are 83% the size of control wings. Wing cell size is unaffected - the wing size reduction is the result of fewer cells. Gross defects in wing patterning are not apparent. There is no significant decrease in the size of other organs or the whole organism.

        ebiP7/ebiW418X larval wing discs have visibly smaller wing pouches.

        Macrochaetes on ebiP7/ebiW418X nota are stunted and form in ectopic positions.

        No or very few ebiW418X clones survive to late third instar stage when induced at 48 hours after egg deposition (AED), and survival is not improved by inducing clones in a Minute/+ background. Clones induced at 72 hours AED do survive, but are very small.

        (Marygold et al., 2011)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        ebi[+]/ebiW418X is an enhancer of abnormal size phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

        (Marygold et al., 2011)

        ebi[+]/ebiW418X is an enhancer of abnormal size phenotype of Scer\GAL4Bx-MS1096, aosUAS.cMa

        (Marygold et al., 2011)
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        ebi[+]/ebiW418X is an enhancer of wing phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

        (Marygold et al., 2011)

        ebi[+]/ebiW418X is an enhancer of wing vein phenotype of Scer\GAL4Bx-MS1096, aosUAS.cMa

        (Marygold et al., 2011)

        ebi[+]/ebiW418X is an enhancer of wing margin phenotype of sdETX4

        (Marygold et al., 2011)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Heterozygosity for ebiW418X enhances the small wing phenotype induced by Scer\GAL4Bx-MS1096-mediated expression of Pi3K92ED954A.Scer\UAS.T:Hsap\MYC.

        Heterozygosity for ebiW418X enhances the small wing and wing vein loss phenotypes induced by Scer\GAL4Bx-MS1096-mediated expression of aosScer\UAS.cMa.

        Heterozygosity for ebiW418X enhances the notched wing margin phenotype seen in sdETX4 hemizygous males.

        (Marygold et al., 2011)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        ebiW418X is rescued by ebi+t7.5

        (Marygold et al., 2011)
        Comments

        ebi+t7.5 rescues the homozygous lethality of ebiW418X.

        (Marygold et al., 2011)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        ebiW418X
        (Marygold et al., 2011)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)