FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PI31UAS.Tag:HA
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General Information
Symbol
Dmel\PI31UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0266169
Feature type
allele
Associated gene
Dmel\PI31
Associated Insertion(s)
Carried in Construct
P{UAS-PI31.HA}
Also Known As
UAS-PI31, UAS-HA-PI31
Key Links
Transgenic product class
wild_type
(Bader et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Bader et al., 2011)
Mutagen
in vitro construct
(Bader et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-PI31.HA}
Cytology
Description

UAS regulatory sequences drive expression of full-length PI31 tagged with a Tag:HA epitope.

(Bader et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
PI31
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  nemaline myopathy 7
      modeled by tsrHMS00534
      (Balakrishnan et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of PI31Scer\UAS.T:Ivir\HA1 using Scer\GAL4tub.PU and Scer\GAL80ts.αTub84B at 23[o]C in a PI31KO background results in viable 'mosaic' adults that lack PI31 function specifically in the germ cells. The testes of these flies are irregular and display a meiotic arrest phenotype, characterized by an abundance of underdeveloped 16-cell stage cysts. Mitosis of germline cells proceeds normally, but meiosis does not. Germ cell differentiation is prevented and a progenitor identity persists.

      (Bader et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of PI31Scer\UAS.T:Ivir\HA1 suppresses the rough eye seen in flies expressing Pros261.B.Scer\UAS and Prosβ21.Scer\UAS using Scer\GAL4GMR.PU at 29[o]C.

      (Bader et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      PI31UAS.Tag:HA/Scer\GAL4Tub.PU rescues PI31KO

      (Bader et al., 2011)
      Comments

      Expression of PI31Scer\UAS.T:Ivir\HA1 using Scer\GAL4tub.PU and Scer\GAL80ts.αTub84B at 23[o]C rescues the lethality, melanotic tumor, reduced larval size and slow development phenotypes of PI31KO animals.

      (Bader et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      PI31Scer\UAS.T:Ivir\HA1
      PI31UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (5)