FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ndc80GL00625
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General Information
Symbol
Dmel\Ndc80GL00625
Species
D. melanogaster
Name
FlyBase ID
FBal0266324
Feature type
allele
Associated gene
Dmel\Ndc80
Associated Insertion(s)
Carried in Construct
P{TRiP.GL00625}
Also Known As
GL00625, Ndc80RNAi, Ndc80 RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
in vitro construct
(Ni et al., 2011.7.19)
Progenitor genotype
Carried in construct
P{TRiP.GL00625}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-GL00625
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Ndc80GL00625 under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 in oocytes does not significantly disrupt kinetochore assembly, prometaphase karyosome configurations, or co-orientation of homologous chromosomes, but does disrupt end-on kinetochore-microtubule attachment formation and centromere orientation towards the spindle pole.

      Expression of Ndc80GL00625 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 in females results in sterility.

      (Radford et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Ndc80GL00625 enhances the karyosome splitting defect of oocytes expressing cmetGL00404 under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 results in karyosome splitting.

      (Radford et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ndc80GL00625
      Ndc80RNAi
      (Shapiro et al., 2025)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)