FlyBase Allele Report: Dmel\frac[UAS.cMa]

General Information

Symbol

Dmel\frac^UAS.cMa

Species

D. melanogaster

Name

FlyBase ID

FBal0266872

Feature type

allele

Associated gene

Dmel\frac

Associated Insertion(s)

Carried in Construct

P{UAS-frac.fl}

Key Links

Transgenic product class

wild_type

(Miller et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Miller et al., 2011)

Mutagen

in vitro construct

(Miller et al., 2011)

Progenitor genotype

Carried in construct

P{UAS-frac.fl}

Cytology

Description

UAS regulatory sequences drive expression of frac.

(Miller et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

frac

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^how-24B

(Miller et al., 2011)

Phenotype Manifest In

larval intersegmental nerve branch ISNb of A1-7 | embryonic stage, with Scer\GAL4^how-24B

(Miller et al., 2011)

Detailed Description

Statement

Reference

Overexpression of frac^Scer\UAS.cMa in motor axons under the control of Scer\GAL4^how-24B results in the ISNb displaying extra projections and misrouted axons.

(Miller et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^elav-C155, Scer\GAL4^how-24B, frac^UAS.cMa has abnormal neuroanatomy | embryonic stage phenotype, suppressible | partially by Scer\GAL4^elav-C155/sax^{Q263D.UAS.Tag:HA}, Scer\GAL4^how-24B

(Miller et al., 2011)

Scer\GAL4^how-24B, frac^UAS.cMa has abnormal neuroanatomy | embryonic stage phenotype, suppressible | partially by sax^{Q263D.UAS.Tag:HA}/Scer\GAL4^how-24B

(Miller et al., 2011)

Scer\GAL4^elav-C155, frac^UAS.cMa has abnormal neuroanatomy | embryonic stage phenotype, suppressible | partially by Scer\GAL4^elav-C155/sax^{Q263D.UAS.Tag:HA}

(Miller et al., 2011)

Scer\GAL4^how-24B, frac^UAS.cMa has abnormal neuroanatomy | embryonic stage phenotype, suppressible by Scer\GAL4^how-24B/gbb^UAS.cKa

(Miller et al., 2011)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^elav-C155, Scer\GAL4^how-24B, frac^UAS.cMa has larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype, suppressible | partially by Scer\GAL4^elav-C155/sax^{Q263D.UAS.Tag:HA}, Scer\GAL4^how-24B

(Miller et al., 2011)

Scer\GAL4^how-24B, frac^UAS.cMa has larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype, suppressible | partially by sax^{Q263D.UAS.Tag:HA}/Scer\GAL4^how-24B

(Miller et al., 2011)

Scer\GAL4^elav-C155, frac^UAS.cMa has larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype, suppressible | partially by Scer\GAL4^elav-C155/sax^{Q263D.UAS.Tag:HA}

(Miller et al., 2011)

Scer\GAL4^how-24B, frac^UAS.cMa has larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype, suppressible by Scer\GAL4^how-24B/gbb^UAS.cKa

(Miller et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of sax^{Q263D.Scer\UAS.T:Ivir\HA1} partially suppresses the motor axon mis-projections and hypo-fasciculation found upon expression of frac^Scer\UAS.cMa (from 55% to 27%, when both transgenes are expressed under the control of either or both Scer\GAL4^elav-C155 and Scer\GAL4^how-24B).

Mesodermal expression of gbb^Scer\UAS.cKa (under the control of Scer\GAL4^how-24B) suppresses the phenotype observed with frac^Scer\UAS.cMa over-expression (48% to 28%).

(Miller et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

frac^Scer\UAS.cMa

frac^UAS.cMa

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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