FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dskf02468b
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General Information
Symbol
Dmel\Dskf02468b
Species
D. melanogaster
Name
FlyBase ID
FBal0267708
Feature type
allele
Associated gene
Dmel\Dsk
Associated Insertion(s)
PBac{WH}Dskf02468b
Carried in Construct
Also Known As
dskf02468
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Chen and Ganetzky, 2012)
Mutagen
P-element activity
(Chen and Ganetzky, 2012)
Progenitor genotype
Associated Insertion(s)
PBac{WH}Dskf02468b
Cytology
Description
Allele components
Component
Use(s)
Inserted element
PBac{WH}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Compared with wild-type, homozygous DskGD6123 mutants exhibit mild neuromuscular junction (NMJ) undergrowth.

      Compared with wild-type, DskGD6123/DskEP3632 mutants exhibit mild NMJ undergrowth.

      Compared with wild-type, hemizygous Dskf02468b/Df(3R)2-2 larvae exhibit pronounced NMJ undergrowth.

      The NMJ undergrowth phenotypes of homozygous Dskf02468b or hemizygous Dskf02468b/Df(3R)2-2 larvae are rescued by Dp(3;1)2-2.

      Dskf02468b/+ heterozygotes do not display NMJ) defects.

      The size and frequency of miniature excitatory junction potentials (mEJPs) from muscle 6 of Dskf02468b/Df(3R)2-2 mutants does not differ from that of wild-type. However, the size of excitatory junction potentials (EJPs) is reduced in Dskf02468b/Df(3R)2-2 mutants compared with wild-type.

      (Chen and Ganetzky, 2012)

      Under dim light conditions, the distance travelled by Dskf02468b/Df(3R)2-2 third instar larvae in one minute at 20-22[o]C is slightly reduced compared to wild type. The frequency of peristaltic contractions under these conditions is also slightly reduced. Under bright light at 27-30[o]C (stress conditions) the mutant larvae travel significantly less far than wild type in one minute. Under these conditions, the frequency of peristaltic contractions is reduced in the mutant larvae compared to wild type.

      (Chen et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Whereas Df(1)Exel9051/+ alone or Dskf02468b/+ heterozygotes alone do not display neuromuscular junction (NMJ) defects, Df(1)Exel9051/+; Dskf02468b/+ double heterozygotes exhibit a strong reduction in synaptic bouton number. In contrast, heterozygosity for Dskf02468b does not further enhance the NMJ undergrowth phenotype of Df(1)Exel9051/Y mutants.

      The NMJ undergrowth phenotype of homozygous Dskf02468b is suppressed by Scer\GAL4elav-C155-driven overexpression of CCKLR-17D1Scer\UAS.cCa.

      (Chen and Ganetzky, 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Dskf02468b is rescued by DskUAS.cCa

      (Chen and Ganetzky, 2012)
      Comments

      The neuromuscular junction (NMJ) undergrowth phenotype of homozygous Dskf02468b larvae is rescued by Scer\GAL4elav-C155-driven expression of DskScer\UAS.cCa.

      (Chen and Ganetzky, 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Dskf02468b
      dskf02468
      (Chen et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)