FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pdcd41
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General Information
Symbol
Dmel\Pdcd41
Species
D. melanogaster
Name
FlyBase ID
FBal0267758
Feature type
allele
Associated gene
Dmel\Pdcd4
Associated Insertion(s)
P+PBac{XP5.WH5}Pdcd41
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Cash and Andrews, 2012)
Mutagen
FLPase
(Cash and Andrews, 2012)
Progenitor genotype
PBac{WH}Pdcd4f06108
(Cash and Andrews, 2012)
P{XP}Pdcd4d04016
(Cash and Andrews, 2012)
Associated Insertion(s)
P+PBac{XP5.WH5}Pdcd41
Cytology
Description

Recombination between PBac{WH}CG10990f06108 and P{XP}CG10990d04016 resulting in loss of 95% of the Pdcd4 coding sequence including the translation initiation codon and the sequences encoding both MA-3 domains.

(Cash and Andrews, 2012)
Allele components
Component
Use(s)
Inserted element
P+PBac{XP5.WH5}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:13,747,408..13,752,677 [-]
Comment:

A deletion resulting from recombination between PBac{WH}Pdcd4f06108 and P{XP}Pdcd4d04016, which causes loss of 95% of the Pdcd4 coding sequence.

(Cash and Andrews, 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes and hemizygotes are viable with no obvious developmental or morphological defects.

      Hemizygous males are fully fertile and show no obvious morphological defects in the adult germline.

      Homozygous, hemizygous and Pdcd41/Pdcd4G93 females are fertile with no obvious morphological defects in the adult germline.

      Homozygous, hemizygous and Pdcd41/Pdcd4G93 germaria have an increased number of spectrosome-containing cells compared to wild type - this number does not increase with age. There are no discernable defects in differentiation or any discernable abnormalities in subsequent germline stages.

      Germline stem cells in Pdcd41 ovaries are present in similar numbers to wild type.

      The expanded population of spectrosome-containing cells in Pdcd41 mutants are pre-cystoblasts.

      (Cash and Andrews, 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Pdcd41 has germarium phenotype, suppressible by eIF-4a[+]/eIF4A1013

      (Cash and Andrews, 2012)
      Other
      Statement
      Reference

      Pdcd41, bam[+]/bamΔ86 has germarium phenotype

      (Cash and Andrews, 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increased number of spectrosome-containing cells in Pdcd41 germaria is significantly decreased in a eIF-4a1013/+ background.

      Pdcd41/Pdcd41, bamΔ86/+ germaria contain significantly more spectrosome-containing cells compared to either Pdcd41/Pdcd41 or bamΔ86/+ alone.

      (Cash and Andrews, 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Pdcd41
      (Cash and Andrews, 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)