FB2026_02 , released June 18, 2026
Allele: Dmel\eIF4A1013
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General Information
Symbol
Dmel\eIF4A1013
Species
D. melanogaster
Name
FlyBase ID
FBal0096982
Feature type
allele
Associated gene
Dmel\eIF4A
Associated Insertion(s)
P{lacW}eIF4A1013
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Galloni and Edgar, 1999)
Progenitor genotype
Associated Insertion(s)
P{lacW}eIF4A1013
Cytology
Description

Insertion into the first intron of eIF-4a.

(Galloni and Edgar, 1999)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Less than 9% of eIF-4a1013 germline stem cells detected 1 week after clone induction (ACI) are detected at 3 weeks ACI, whereas 76% of control germline stem cells detected 1 week ACI are detected at 3 weeks ACI.

      (Shen et al., 2009)

      Larval growth arrest, in L1. 28% survive until 4 days after hatching. DNA replication continues at a reduced level compared to wild type. Mutant phenotype is cell autonomous. Mutant clones in the wing disc are occasionally detectable. All adults in which clones had been induced show a rough eye phenotype. Mutant clones in the eye produce a rough eye phenotype, almost no mutant cells are detected.

      (Galloni and Edgar, 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      eIF-4a[+]/eIF4A1013 is a suppressor of female sterile phenotype of bamz3-2884/bamΔ86

      (Shen et al., 2009)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      eIF-4a[+]/eIF4A1013 is a suppressor of germarium phenotype of Pdcd41

      (Cash and Andrews, 2012)

      eIF-4a[+]/eIF4A1013 is a suppressor of ovariole phenotype of bamz3-2884/bamΔ86

      (Shen et al., 2009)

      eIF-4a[+]/eIF4A1013 is a suppressor of germarium phenotype of bamz3-2884/bamΔ86

      (Shen et al., 2009)

      eIF-4a[+]/eIF4A1013 is a suppressor of female germline stem cell | increased number phenotype of bamz3-2884/bamΔ86

      (Shen et al., 2009)
      NOT Suppressor of
      Statement
      Reference

      eIF-4a[+]/eIF4A1013 is a non-suppressor of germarium phenotype of bamΔ86

      (Shen et al., 2009)

      eIF-4a[+]/eIF4A1013 is a non-suppressor of ovariole phenotype of bamΔ86

      (Shen et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increased number of spectrosome-containing cells in Pdcd41 germaria is significantly decreased in a eIF-4a1013/+ background.

      (Cash and Andrews, 2012)

      Most bamz3-2884/bamΔ86; eIF-4a1013/+ ovarioles contain 4-6 normal egg chambers, while the germaria contain fewer single germ cells compared to bamz3-2884/bamΔ86 ovarioles.

      eIF-4a1013 fails to dominantly suppress the tumourous phenotype of bamΔ86 ovarioles.

      (Shen et al., 2009)

      No reduction in pole cell number is seen in the progeny of vasPH165/+ ; eIF-4a1013/+ females.

      (Carrera et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      eIF4AYE9

      (Li et al., 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision of the P-element is accompanied by reversion of the mutant phenotype.

      (Galloni and Edgar, 1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      EIF4A1013
      (Linsalata et al., 2019)
      eIF-4a1013
      eIF4A1013
      (Wang et al., 2025, Cash and Andrews, 2012, Shen et al., 2009, Li et al., 2005, Carrera et al., 2000)
      eif4A1013
      (Galloni and Edgar, 1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)