FlyBase Allele Report: Dmel\kug[N103-2]

General Information

Symbol

Dmel\kug^N103-2

Species

D. melanogaster

Name

FlyBase ID

FBal0267777

Feature type

allele

Associated gene

Dmel\kug

Associated Insertion(s)

Carried in Construct

Also Known As

fat2^N103-2

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Horne-Badovinac et al., 2012)

Progenitor genotype

Cytology

Description

Complex lesion leading to a premature stop codon at position 3718.

(Horne-Badovinac et al., 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult antennal lobe glomerulus

(Vien et al., 2024)

adult antennal lobe glomerulus (with kug^58D)

(Vien et al., 2024)

adult antennal lobe glomerulus | P-stage

(Vien et al., 2024)

adult antennal olfactory receptor neuron

(Vien et al., 2024)

adult antennal olfactory receptor neuron (with kug^58D)

(Vien et al., 2024)

adult antennal olfactory receptor neuron | P-stage

(Vien et al., 2024)

adult olfactory receptor neuron Ir64a

(Vien et al., 2024)

adult olfactory receptor neuron Ir76a ac4

(Vien et al., 2024)

adult olfactory receptor neuron Ir92a

(Vien et al., 2024)

adult olfactory receptor neuron Or19

(Vien et al., 2024)

adult olfactory receptor neuron Or22

(Vien et al., 2024)

adult olfactory receptor neuron Or23a

(Vien et al., 2024)

adult olfactory receptor neuron Or47b

(Vien et al., 2024)

adult olfactory receptor neuron Or69a

(Vien et al., 2024)

adult olfactory receptor neuron Or88a

(Vien et al., 2024)

antenna

(Vien et al., 2024)

antennal lobe glomerulus D | absent

(Vien et al., 2024)

antennal lobe glomerulus VA1v | adult stage

(Vien et al., 2024)

antennal lobe glomerulus VA1v | adult stage (with kug^58D)

(Vien et al., 2024)

egg

(Stedden et al., 2019)

egg | somatic clone

(Horne-Badovinac et al., 2012)

follicle cell

(Williams and Horne-Badovinac, 2024, Lerner et al., 2013)

follicle cell | somatic clone

(Stedden et al., 2019)

oocyte associated follicular epithelium

(Barlan et al., 2017)

oocyte associated follicular epithelium | cell non-autonomous | somatic clone

(Barlan et al., 2017)

Detailed Description

Statement

Reference

In kug^N103-2 mutants, follicular epithelium migration is blocked; kug^N103-2 heterozygous eggs are slightly but significantly rounder than controls.

(Stedden et al., 2019)

kug^N103-2 mutant follicular epithelia fail to undergo migration, in contrast to controls.

kug^N103-2 mutant cells in mosaic follicular epithelia exhibit a non-cell-autonomous defect in leading edge protrusion formation, as wild type cells positioned directly behind kug^N103-2 mutant cells lack protrusions, whereas kug^N103-2 cells positioned directly behind wild type cells form protrusions normally. When a cell's leading edge contacts both a kug^N103-2 cell and a wild type cell, protrusions are lost only from the region contacting the kug^N103-2 cell. kug^N103-2 mutant cells also exhibit significantly elongated basal surfaces, indicative of a defect in trailing edge retraction.

(Barlan et al., 2017)

Follicle cell epithelia fail to migrate in mutant females.

(Lerner et al., 2013)

Females carrying homozygous follicle cell clones produce round eggs.

(Horne-Badovinac et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

kug^N103-2 has visible | oogenesis | dominant phenotype, enhanceable by Sema5c^K175/Sema5c^K175

(Stedden et al., 2019)

kug^N103-2 has abnormal size | oogenesis | dominant phenotype, enhanceable by Sema5c^K175/Sema5c^K175

(Stedden et al., 2019)

Enhancer of

Statement

Reference

kug^N103-2/kug[+] is an enhancer of abnormal neuroanatomy | adult stage phenotype of Apc^HMS00188, Scer\GAL4^peb-GAL4

(Vien et al., 2024)

kug^N103-2/kug[+] is an enhancer of abnormal neuroanatomy | adult stage phenotype of Scer\GAL4^peb-GAL4, dop^HMC05132

(Vien et al., 2024)

NOT Enhancer of

Statement

Reference

kug^N103-2/kug[+] is a non-enhancer of abnormal size | oogenesis phenotype of Sema5c^K175

(Stedden et al., 2019)

kug^N103-2/kug[+] is a non-enhancer of visible | oogenesis phenotype of Sema5c^K175

(Stedden et al., 2019)

Suppressor of

Statement

Reference

kug^N103-2/kug[+] is a suppressor of abnormal neuroanatomy | adult stage phenotype of Apc2^N175K, Apc^Q8

(Vien et al., 2024)

Phenotype Manifest In

Enhanced by

Statement

Reference

kug^N103-2 has egg phenotype, enhanceable by Sema5c^K175/Sema5c^K175

(Stedden et al., 2019)

Enhancer of

Statement

Reference

kug^N103-2/kug[+] is an enhancer of adult antennal lobe glomerulus phenotype of Apc^HMS00188, Scer\GAL4^peb-GAL4

(Vien et al., 2024)

kug^N103-2/kug[+] is an enhancer of adult antennal lobe glomerulus phenotype of Scer\GAL4^peb-GAL4, dop^HMC05132

(Vien et al., 2024)

NOT Enhancer of

Statement

Reference

kug^N103-2/kug[+] is a non-enhancer of egg phenotype of Sema5c^K175

(Stedden et al., 2019)

Suppressor of

Statement

Reference

kug^N103-2/kug[+] is a suppressor of adult antennal lobe glomerulus phenotype of Apc2^N175K, Apc^Q8

(Vien et al., 2024)

kug^N103-2/kug[+] is a suppressor of adult antennal olfactory receptor neuron phenotype of Apc2^N175K, Apc^Q8

(Vien et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

605816

w^*; kug^N103-2 P{neoFRT}80B/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Fat2^N103-2

(Cerqueira Campos et al., 2020)

fat2^N103-2

(Williams and Horne-Badovinac, 2024, Williams et al., 2022, Stedden et al., 2019, Barlan et al., 2017, Isabella and Horne-Badovinac, 2016, Lerner et al., 2013, Horne-Badovinac et al., 2012)

fat2^N103.2

(Stedden et al., 2019)

fat2N103-2

(Vien et al., 2024)

kug^N103-2

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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