FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Caf1-55p55-2
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General Information
Symbol
Dmel\Caf1-55p55-2
Species
D. melanogaster
Name
FlyBase ID
FBal0267806
Feature type
allele
Associated gene
Dmel\Caf1-55
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Wen et al., 2012)
Progenitor genotype
P{SUPor-P}CG31344KG02618
(Wen et al., 2012)
Cytology
Description

Imprecise excision of the P{SUPor-P} element in P{SUPor-P}CG31344KG02618 resulted in a 1602bp deletion which removes the first exon, the second exon and part of the third exon of Caf1, leaving only the third exon of the coding region and the 3'UTR

(Wen et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:15,225,357..15,226,958 [+]
Comment:

Inferred boundaries of a 2244 bp deletion resulting from the imprecise excision of P{SUPor-P}CG31344KG02618, which removes most of the Caf1-55 coding region.

(Wen et al., 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous Caf1p55-2 mutants are 1-2 days developmentally delayed compared to wild type and the body size is greatly reduced. Some mutant larvae survive for up to 6-8 days, but they never undergo pupariation.

      Caf1p55-1/Caf1p55-2 mutants are 1-2 days developmentally delayed compared to wild type and the body size is greatly reduced. Some mutant larvae survive for up to 6-8 days, but they never undergo pupariation.

      Homozygous mutant Caf1p55-2 GSC clones are lost more quickly than in controls. TUNEL staining shows that this is due to differentiation rather than apoptosis.

      (Wen et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      Caf1-55p55-2 has lethal | second instar larval stage phenotype, non-suppressible by CG31344tWa

      (Wen et al., 2012)
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      Caf1-55p55-2/Caf1[+] is a non-enhancer of sex comb | ectopic phenotype of Pc15

      (Wen et al., 2012)
      NOT Suppressor of
      Statement
      Reference

      Caf1-55p55-2/Caf1[+] is a non-suppressor of sex comb | ectopic phenotype of Pc15

      (Wen et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      CG31344tWa is unable to rescue the lethality seen in homozygous Caf1p55-2 mutants.

      Caf1p55-2/+ does not affect the ectopic sex comb phenotype seen in Pc15 heterozygotes.

      (Wen et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Caf1-55p55-2/Caf1-55p55-1 is rescued by Caf1-55+t1.3p55

      (Wen et al., 2012)
      Partially rescued by

      Caf1-55p55-2/Caf1-55p55-1 is partially rescued by Caf1-551.3p55m

      (Wen et al., 2012)
      Not rescued by

      Caf1-55p55-2/Caf1-55p55-1 is not rescued by Caf1-55t0.5p55

      (Wen et al., 2012)
      Comments

      Expression of Caf1+t1.3p55 fully rescues the lethality and developmental delay phenotypes seen in Caf1p55-1/Caf1p55-2 mutants.

      Expression of Caf1t0.5p55 is unable to rescue the lethality and developmental delay phenotypes seen in Caf1p55-1/Caf1p55-2 mutants.

      Expression of Caf11.3p55m partially rescues the lethality and developmental delay phenotypes seen in Caf1p55-1/Caf1p55-2 mutants. The rescued flies are fertile and can be maintained as a stable stock.

      (Wen et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Caf1-55p55-2
      Caf1p55-2
      p552
      (Wen et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)