FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nmdar2RNAi.UAS.cWa
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General Information
Symbol
Dmel\Nmdar2RNAi.UAS.cWa
Species
D. melanogaster
Name
FlyBase ID
FBal0268133
Feature type
allele
Associated gene
Dmel\Nmdar2
Associated Insertion(s)
Carried in Construct
P{UAS-Nmdar2.RNAi.W}
Also Known As
UAS-dsNR2
Key Links
Transgenic product class
RNAi_reagent
(Wu et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Wu et al., 2007)
Mutagen
in vitro construct
(Wu et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-Nmdar2.RNAi.W}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat of Nmdar2 sequence, which consists of nucleotides 2898-3741 of the coding sequence in sense orientation and nucleotides 3852-2898 of the coding sequence in antisense orientation.

(Wu et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Nmdar2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The gross morphology of the ellipsoid body is normal in animals expressing Nmdar2dsRNA.Scer\UAS.cWa under the control of Scer\GAL4Feb170.

      1 day memory is impaired after spaced training, but not after massed training in an olfactory associative conditioning assay in flies expressing Nmdar2dsRNA.Scer\UAS.cWa under the control of Scer\GAL4Feb170. 3 hour memory after one session of training is normal in these flies.

      Use of the temperature sensitive Scer\GAL80ts.αTub84B allele is used to restrict Scer\GAL4 expression indicates that the disruption of 1 day memory caused by expression of Nmdar2dsRNA.Scer\UAS.cWa under the control of Scer\GAL4Feb170 is due to an effect on consolidation and storage of long term memory, and not due to an effect on retrieval of memory.

      1 day memory after spaced or massed training in an olfactory associative conditioning assay is not affected in flies expressing Nmdar2dsRNA.Scer\UAS.cWa under the control of Scer\GAL4ey-OK107. 3 hour anesthesia-sensitive memory is impaired in these flies compared to controls.

      (Wu et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      1 day memory is impaired after spaced training, but not after massed training in an olfactory associative conditioning assay in flies co-expressing Nmdar1dsRNA.Scer\UAS.cWa and Nmdar2dsRNA.Scer\UAS.cWa under the control of Scer\GAL4G0431. The defect in memory after spaced training is still seen if the temperature sensitive Scer\GAL80ts.αTub84B allele is used to restrict Scer\GAL4 expression to the adult stage.

      (Chen et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Nmdar2RNAi.UAS.cWa
      Nmdar2dsRNA.Scer\UAS.cWa
      Nmdar2dsRNA.UAS.cWa
      dsNR2
      (Chen et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)