FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ich206
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General Information
Symbol
Dmel\ich206
Species
D. melanogaster
Name
FlyBase ID
FBal0268643
Feature type
allele
Associated gene
Dmel\ich
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Rosa et al., 2018)
Mutagen
ethyl methanesulfonate
(Ghabrial et al., 2011)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q107term.

(Rosa et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:8,953,532..8,953,532 [-]
Nucleotide change:

C8953532T

Amino acid change:

Q107term | ich-PA; Q107term | ich-PB

Reported amino acid change:

Q107term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Rosa et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Terminal tracheal cell clones mutant for ich206 in mosaic third instar larvae display seamless tube defects, namely discontinuous membrane-bounded lumens with an irregular cystic appearance. Scer\GAL4btl.PS-driven expression of ichScer\UAS.cRa in the mosaic larvae strongly rescues the tube discontinuity in the mutant cells but gain-of-function morphological defects such as terminal cell pruning are also observed.

      ich206 mutant embryos exhibit mild 'blimp' (bloated) defects in cuticular preparations along with reduced sclerotization of the head skeleton and ventral epidermal denticles.

      (Rosa et al., 2018)

      ichor206 mutants exhibit a terminal cell gas-filing defect. They are defective in matrix clearance in all seamless tubes: mutant terminal cels have normal morphology and form seamless tubes, but the tubes fail to clear and gas-fill.

      (Ghabrial et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The integrity defects of the seamless tube in terminal tracheal cell clones mutant for ich206 in third instar larvae is weakly suppressed by Scer\GAL4btl.PS-driven expression of lintScer\UAS.cRa - about 2% of clones are rescued and that only if the larvae are kept at 29[o]C to boost the transgene expression.

      (Rosa et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      ich206 is partially rescued by ichUAS.cRa/Scer\GAL4btl.PS

      (Rosa et al., 2018)

      ich206 is partially rescued by ichUAS.Tag:FLAG/Scer\GAL4btl.PS

      (Rosa et al., 2018)

      ich206 is partially rescued by Scer\GAL4btl.PS/ichDBD.VP16.UAS.Tag:FLAG.Tag:NLS(SV40-largeT)

      (Rosa et al., 2018)
      Comments

      The discontinuous seamless tube phenotype observed in terminal tracheal cell clones mutant for ich206 in mosaic third instar larvae is partially rescued by Scer\GAL4btl.PS-driven expression of any of the following ichScer\UAS.cRa, ichDBD.Scer\UAS.T:Zzzz\FLAG.T:SV40\nls-largeT.T:Hsim\VP16 or ichScer\UAS.T:Zzzz\FLAG : the proportion of ich206 terminal cells with seamless tube discontinuities is much decreased.

      (Rosa et al., 2018)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      206
      (Ghabrial et al., 2011)
      ich206
      (Rosa et al., 2018)
      ichor206
      ichorous206
      Name Synonyms
      Secondary FlyBase IDs
        References (2)