FlyBase Allele Report: Dmel\Arp3[515FC]

General Information

Symbol

Dmel\Arp3^515FC

Species

D. melanogaster

Name

FlyBase ID

FBal0269076

Feature type

allele

Associated gene

Dmel\Arp3

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: W378term.

(Rajan et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:8,114,141..8,114,141 [-]

Nucleotide change:

G8114141A

Amino acid change:

W378term | Arp3-PA; W378term | Arp3-PB

Reported amino acid change:

W378term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Rajan et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Rajan et al., 2009)

lethal (with Arp3^EP3640)

(Rajan et al., 2009)

Phenotype Manifest In

external sensory organ precursor cell IIa | somatic clone

(Rajan et al., 2009)

external sensory organ precursor cell IIb | somatic clone

(Rajan et al., 2009)

female germline cyst | somatic clone

(Rajan et al., 2009)

mechanosensory chaeta | somatic clone

(Rajan et al., 2009)

stalk follicle cell | somatic clone

(Rajan et al., 2009)

Detailed Description

Statement

Reference

Arp3^515FC clones in the adult thorax show bristle loss.

Arp3^515FC clones in anterior polar follicle cells results in loss of stalk cells and partial fusion of adjacent cysts.

Arp3^515FC pIIa-pIIb cells have fewer finger-like projections (microvilli) than wild type cells.

(Rajan et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Arp3^515FC/Arp3[+] is a suppressor | partially of nurse cell ring canal phenotype of Scer\GAL4^{VP16.mat.αTub67C}, dock^{UASp.Tag:HA,Tag:Myr(Unk)}

(Stark et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

39727

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}80B Arp3^515FC/TM3, P{GAL4-Kr.C}DC2, P{UAS-GFP.S65T}DC10, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Arp3^515FC

(Trylinski and Schweisguth, 2019, Rajan et al., 2009)

Arp66B^515FC

arp3^515FC

(Stark et al., 2021, Herszterg et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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