FlyBase Allele Report: Dmel\foxo[UASp.cSa]

General Information

Symbol

Dmel\foxo^UASp.cSa

Species

D. melanogaster

Name

FlyBase ID

FBal0269839

Feature type

allele

Associated gene

Dmel\foxo

Associated Insertion(s)

Carried in Construct

P{UASp-foxo.S}

Also Known As

UAS-foxo

Key Links

Transgenic product class

wild_type

(Slack et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Slack et al., 2011)

Mutagen

in vitro construct

(Slack et al., 2011)

Progenitor genotype

Carried in construct

P{UASp-foxo.S}

Cytology

Description

UASp regulatory sequences drive expression of foxo coding sequences.

(Slack et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

foxo

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4²²¹

(Bhattacharjee et al., 2022)

fertile, with Scer\GAL4^{VP16.mat.αTub67C}

(Slack et al., 2011)

Phenotype Manifest In

dendrite, with Scer\GAL4²²¹

(Bhattacharjee et al., 2022)

dendritic branch | increased number, with Scer\GAL4²²¹

(Bhattacharjee et al., 2022)

intestinal stem cell, with Scer\GAL4^esg.PU

(Xing et al., 2015)

multidendritic neuron, with Scer\GAL4²²¹

(Bhattacharjee et al., 2022)

Detailed Description

Statement

Reference

Expression of foxo^{Scer\UAS.P\T.cSa} under the control of Scer\GAL4^esg.PU significantly reduces the intestinal stem cell population.

(Xing et al., 2015)

Flies expressing foxo^{Scer\UAS.P\T.cSa} in the germline under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} are fertile, with no overall gross morphological defects in ovarian structure. However, egg laying by these females is reduced by approximately 30%.

(Slack et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4²²¹, foxo^UASp.cSa has abnormal neuroanatomy phenotype, suppressible by Scer\GAL4²²¹/mts^UAS.cHa

(Bhattacharjee et al., 2022)

Suppressor of