FlyBase Allele Report: Dmel\dpr11[MI02231]

General Information

Symbol

Dmel\dpr11^MI02231

Species

D. melanogaster

Name

FlyBase ID

FBal0269917

Feature type

allele

Associated gene

Dmel\dpr11

Associated Insertion(s)

Mi{MIC}dpr11^MI02231

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

Mi{MIC}dpr11^MI02231

Cytology

Description

Allele components

Component

Use(s)

Inserted element

Also carries

integrase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:6,586,294..6,586,294 [-]

(Courgeon and Desplan, 2019, Menon et al., 2019, Carrillo et al., 2015, Bellen, 2012.6.14)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage

(Carrillo et al., 2015)

abnormal neuroanatomy | third instar larval stage (with Df(3R)BSC193)

(Carrillo et al., 2015)

abnormal neurophysiology | third instar larval stage (with Df(3R)BSC193)

(Carrillo et al., 2015)

viable

(Carrillo et al., 2015)

viable (with Df(3R)BSC193)

(Carrillo et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

dpr11^MI02231/dpr11^MI02231 or dpr11^MI02231/Df(3R)BSC193 third instar larvae have extra satellite (supernumerary) boutons at the neuromuscular junction (NMJ) compared to wild type and heterozygotes (measured at muscle 4). dpr11^MI02231/Df(3R)BSC193 third instar larvae show significant increases in miniature excitatory postsynaptic potential (mEPSP) amplitude and frequency (but no difference in evoked responses) compared to controls.

Terminals of R7 photoreceptor cells of yellow ommatidia (yR7) are bulb-shaped and regularly arranged in layer 6 of the medulla (M6) in dpr11^MI02231/+ adult flies, with less than 10% of terminals having nub-like overshoots that extend deeper into M6; terminals in dpr11^MI02231/Df(3R)BSC193 adults have irregular shapes, are not lined up in a fixed position along the vertical axis, and show a significant increase (30%) of overshoots, even extending into the M7 layer. This phenotype becomes detectable in dpr11^MI02231/Df(3R)BSC193 animals at 70hr APF (no differences compared to controls at 25 or 50hr APF).

(Carrillo et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

dpr11^MI02231/Df(3R)BSC193 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by DIP-γ^MI03222/Df(3R)Exel6210

(Carrillo et al., 2015)

NOT Enhancer of

Statement

Reference

dpr11^MI02231/Df(3R)BSC193 is a non-enhancer of abnormal neuroanatomy | third instar larval stage phenotype of DIP-γ^MI03222/Df(3R)Exel6210

(Carrillo et al., 2015)

Other

Statement

Reference

DIP-γ^MI03222/DIP-gamma[+], dpr11^MI02231 has abnormal neuroanatomy | third instar larval stage phenotype

(Carrillo et al., 2015)

Dad^j1E4/Dad[+], dpr11^MI02231 has abnormal neuroanatomy | third instar larval stage phenotype

(Carrillo et al., 2015)

Scer\GAL4^elav.PU, dpr11^MI02231, tkv^{Q199D.UAS.Tag:HA} has abnormal neuroanatomy | third instar larval stage phenotype

(Carrillo et al., 2015)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

dpr11^MI02231/Df(3R)BSC193 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, non-enhanceable by DIP-γ^MI03222/Df(3R)Exel6210

(Carrillo et al., 2015)

dpr11^MI02231/Df(3R)BSC193 has NMJ bouton | third instar larval stage | increased number phenotype, non-enhanceable by DIP-γ^MI03222/Df(3R)Exel6210

(Carrillo et al., 2015)

NOT Enhancer of

Statement

Reference

dpr11^MI02231/Df(3R)BSC193 is a non-enhancer of embryonic/larval neuromuscular junction | third instar larval stage phenotype of DIP-γ^MI03222/Df(3R)Exel6210

(Carrillo et al., 2015)

dpr11^MI02231/Df(3R)BSC193 is a non-enhancer of NMJ bouton | third instar larval stage | increased number phenotype of DIP-γ^MI03222/Df(3R)Exel6210

(Carrillo et al., 2015)

Other

Statement

Reference

DIP-γ^MI03222/DIP-gamma[+], dpr11^MI02231 has embryonic/larval neuromuscular junction | third instar larval stage phenotype

(Carrillo et al., 2015)

DIP-γ^MI03222/DIP-gamma[+], dpr11^MI02231 has NMJ bouton | increased number | third instar larval stage phenotype

(Carrillo et al., 2015)

Dad^j1E4/Dad[+], dpr11^MI02231 has embryonic/larval neuromuscular junction | third instar larval stage phenotype

(Carrillo et al., 2015)

Dad^j1E4/Dad[+], dpr11^MI02231 has NMJ bouton | increased number | third instar larval stage phenotype

(Carrillo et al., 2015)

Scer\GAL4^elav.PU, dpr11^MI02231, tkv^{Q199D.UAS.Tag:HA} has embryonic/larval neuromuscular junction | third instar larval stage phenotype

(Carrillo et al., 2015)

Scer\GAL4^elav.PU, dpr11^MI02231, tkv^{Q199D.UAS.Tag:HA} has NMJ bouton | increased number | third instar larval stage phenotype

(Carrillo et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

dpr11^MI02231/+;DIP-γ^MI03222/+ transheterozygote third instar larvae have extra satellite boutons at the neuromuscular junction (NMJ) compared to wild type and heterozygotes (measured at muscle 4). dpr11^MI02231,Df(3R)Exel6210/Df(3R)BSC193,DIP-γ^MI03222 double mutants show similar increases (non-enhanceable) in NMJ bouton number as dpr11^MI02231/Df(3R)BSC193 or DIP-γ^MI03222/Df(3R)Exel6210 third instar larvae.

dpr11^MI02231/Dad^j1E4 transheterozygote third instar larvae have extra satellite boutons at the neuromuscular junction (NMJ) compared to wild type and heterozygotes.

Expression of tkv^{Q199D.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^elav.PU in a dpr11^MI02231/+ background leads to extra satellite boutons at the neuromuscular junction (NMJ) of third instar larvae.

(Carrillo et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

dpr11^MI02231 is rescued by dpr11^{UAS.ORF.GW.Tag:HA}/Scer\GAL4^elav.PU

(Carrillo et al., 2015)

dpr11^MI02231 is rescued by dpr11^{UAS.ORF.GW.Tag:HA}/Scer\GAL4^{Mhc.Switch.PO}

(Carrillo et al., 2015)

Comments

Expression of dpr11^{Scer\UAS.ORF.GW.T:Ivir\HA1} driven by Scer\GAL4^elav.PU or Scer\GAL4^{Mhc.Switch.PO} (with RU486 feeding) reduces satellite bouton number at the NMJ of dpr11^MI02231 third instar larvae.

(Carrillo et al., 2015)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

40181

y¹ w^*; Mi{MIC}dpr11^MI02231

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Dpr11^MI02231

(Courgeon and Desplan, 2019)

dpr11^MI02231

(Bellen, 2012.6.14)

dpr11^Mi02231

(Zhou et al., 2023)

dpr11<up>MiMIC MI02231 5'>EGFP</up>

(Carrillo et al., 2015)

dpr11^MiMIC

(Carrillo et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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