FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\TRAP1UAS.cBa
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General Information
Symbol
Hsap\TRAP1UAS.cBa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Butler
FlyBase ID
FBal0269969
Feature type
allele
Associated gene
Hsap\TRAP1
Associated Insertion(s)
Carried in Construct
P{UAS-hTRAP1.B}
Also Known As
UAS-hTRAP1
Key Links
Transgenic product class
cDNA
(Butler et al., 2012)
wild_type
(Butler et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Butler et al., 2012)
wild_type
(Butler et al., 2012)
Mutagen
in vitro construct
(Butler et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-hTRAP1.B}
Cytology
Description

UAS regulatory sequences drive expression of a Hsap\TRAP1 cDNA.

(Butler et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\TRAP1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Pink1B9
      (Zhang et al., 2013)
      modeled by Hsap\SNCAA53T.UAS.cKa
      (Butler et al., 2012)
      DOES NOT ameliorate  Parkinson's disease
      modeled by park25
      (Zhang et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Hsap\TRAP1Scer\UAS.cBa under the control of Scer\GAL4Ddc.PL do not show significant defects in climbing ability, even at 4 weeks of age.

      (Butler et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\TRAP1Scer\UAS.cBa under the control of Scer\GAL4da.G32 partially rescues the abnormal wing posture and thorax indentations seen in Pink1B9/Y flies. The reduced climbing index seen in Pink1B9/Y flies is suppressed, while the reduction in flight ability is not suppressed in the rescued flies.

      Expression of Hsap\TRAP1Scer\UAS.cBa under the control of Scer\GAL4da.G32 rescues the vacuolisation and abnormal mitochondrial morphology seen in the indirect flight muscles of Pink1B9/Y flies.

      Expression of Hsap\TRAP1Scer\UAS.cBa under the control of Scer\GAL4da.G32 does not significantly rescue the abnormal wing posture, reduced climbing ability or indirect flight muscle defects of homozygous park25 flies.

      (Zhang et al., 2013)

      Co-expression of Hsap\TRAP1Scer\UAS.cBa suppresses the reduction in the number of ple-positive neurons in the PPM1/2 cluster which is seen in adults expressing Hsap\SNCAA53T.Scer\UAS.cKa under the control of Scer\GAL4Ddc.PL.

      Co-expression of Hsap\TRAP1Scer\UAS.cBa significantly rescue the age-related deficit in climbing ability seen in adults expressing Hsap\SNCAA53T.Scer\UAS.cKa under the control of Scer\GAL4Ddc.PL.

      The rough eye phenotype caused by expression of Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.long is not suppressed by co-expression of Hsap\TRAP1Scer\UAS.cBa.

      (Butler et al., 2012)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\TRAP1Scer\UAS.cBa
      Hsap\TRAP1UAS.cBa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Butler
      Secondary FlyBase IDs
        References (2)