FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\LamCNIG.10119R
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General Information
Symbol
Dmel\LamCNIG.10119R
Species
D. melanogaster
Name
FlyBase ID
FBal0270330
Feature type
allele
Associated gene
Dmel\LamC
Associated Insertion(s)
Carried in Construct
P{NIG.10119R}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
in vitro construct
(Japanese National Institute of Genetics, 2012.5.21)
Progenitor genotype
Carried in construct
P{NIG.10119R}
Cytology
Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-10119R
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of LamCNIG.10119R under the control of Scer\GAL4sr-md710 results in early pupal lethality in 17% of cases, head eversion defects in 73% of cases, and pupal lethality after head eversion in 6% of cases. Only 4% of the animals emerge as adults. Mislocated muscles are seen in the mutant pupae.

      Larvae expressing LamCNIG.10119R under the control of Scer\GAL4sr-md710 do not show the normal regular distribution of tendon cells from 2 days after hatching onwards. This defect in tendon cell distribution is most obvious in pupae which have failed to undergo head eversion. The morphology of the tendon cell nuclei is abnormal in the mutant third instar larvae and tendons are seen detaching from the ends of contracting muscles.

      Expression of LamCNIG.10119R under the control of Scer\GAL4how-24B results in early pupal lethality in 12% of cases and head eversion defects in 88% of cases. None of the animals emerge as adults. Mislocated muscles are seen in the mutant pupae.

      (Uchino et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      LamCNIG.10119R
      Name Synonyms
      Secondary FlyBase IDs
        References (2)