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General Information
Symbol
Dmel\SmoxNIG.2262R
Species
D. melanogaster
Name
FlyBase ID
FBal0273106
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a 500bp inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of SmoxNIG.2262R under the control of Scer\GAL4nub.PU (together with Dicer-2, for efficient RNAi) leads to the adult wing showing a significant decrease in size, associated with a decrease in cell number and with a significant increase in cell size, as compared to controls; these wing also develop ectopic veins around the longitudinal L5 vein. Expression of SmoxNIG.2262R also leads to significant decreases of the adult leg size (Scer\GAL4Dll-md23-driven expression + Dicer-2) and of the salivary gland nucleus size (Scer\GAL4AB1-driven expression + Dicer-2), as compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
NOT Enhanced by
Suppressed by
NOT suppressed by
Enhancer of
Suppressor of
Phenotype Manifest In
Enhanced by
NOT Enhanced by
Statement
Reference
Suppressed by
NOT suppressed by
Statement
Reference
Enhancer of
Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

The decreased wing size induced by the expression of SmoxNIG.2262R under the control of Scer\GAL4nub.PU (together with Dicer-2, for efficient RNAi) is enhanced by the co-expression of either CycEJF02473 or stgNIG.1395R, but is not suppressed by the co-expression of either CycEScer\UAS.cUa or stgScer\UAS.cNa.

The double co-expression either of SmoxNIG.2262R and ykiGD11187 or of SmoxNIG.2262R and InRK1409A.Scer\UAS, under the control of Scer\GAL4nub.PU (together with Dicer-2, for efficient RNAi), leads to a more severe decrease in wing size compared to all corresponding single expression conditions. The co-expression of InRK1409A.Scer\UAS suppresses the increased wing cell size, but does not affect the decreased wing cell number, induced by the expression of SmoxNIG.2262R under the control of Scer\GAL4nub.PU.

The double co-expression either of hpoKK101704 and SmoxNIG.2262R or of PtenGD13500 and SmoxNIG.2262R under the control of Scer\GAL4nub.PU (together with Dicer-2, for efficient RNAi) suppresses the wing defects induced by the single expression conditions.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
SmoxNIG.2262R
Name Synonyms
Secondary FlyBase IDs
    References (3)