FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\shgNIG.3722R
Open Close
General Information
Symbol
Dmel\shgNIG.3722R
Species
D. melanogaster
Name
FlyBase ID
FBal0273928
Feature type
allele
Associated gene
Dmel\shg
Associated Insertion(s)
Carried in Construct
P{NIG.3722R}
Also Known As
E-Cad RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
in vitro construct
(Japanese National Institute of Genetics, 2012.5.21)
Progenitor genotype
Carried in construct
P{NIG.3722R}
Cytology
Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-3722R
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  prostate cancer
      CEA
      (Ito et al., 2014)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  gastrointestinal system cancer
      modeled by Apc2g10, ApcQ8
      (Wang et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of shgNIG.3722R under the control of Scer\GAL4e22c does not induce formation of syncytia in third instar larval epidermis.

      (Wang et al., 2015)

      10 day old male flies expressing shgNIG.3722R in the adult accessory gland under the control of Scer\GAL4esg-NP7397 exhibit a significant decrease in the number of secondary cells compared to controls.

      (Ito et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      shgNIG.3722R/Scer\GAL4Act.PU is an enhancer of hyperplasia | somatic clone phenotype of Apc2g10, ApcQ8

      (Wang et al., 2013)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of shgNIG.3722R under the control of Scer\GAL4Act.PU enhances the formation of multicellular epithelia seen in Apc2g10 ApcQ8 double mutant clones. Enterocytes and enteroendocrine cells are both present and the ratio of differentiated cells to progenitor cells is similar to that observed in Apc2g10 ApcQ8 clones alone. The apicobasal polarity of the clone cells is also unaffected.

      (Wang et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ECADRNAi#3
      (Wang et al., 2015)
      shgNIG.3722R
      Name Synonyms
      Secondary FlyBase IDs
        References (7)