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General Information
Symbol
Dmel\Rap1V12.hs2sev
Species
D. melanogaster
Name
FlyBase ID
FBal0276782
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
sev.rapV12
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

A 1.2kb restriction fragment containing a copy of the sev enhancer guides the expression of a mutated R sequence expressed from an Hsp70 promoter.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

RV12.hs2sev flies exhibit rough eyes from the exterior and in tangential section show ommatidia containing supernumerary small rhabdomere cells. Two copies of Ras85DV12.sev increases the strength of the phenotype, with an abundance of supernumerary small rhabdomere cells.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The eye roughening and multiple R7 phenotype of RV12.hs2sev mutants is significantly suppressed by the loss of one copy of rl (in rl10a or Df(2R)M41A10 heterozygotes).

The presence of RV12.hs2sev in a sev14 homozygous background suppresses the R7 photoreceptor loss seen in sev14 mutants.

Introduction of RV12.hs2sev clones in sev14 eye tissue results in normally constructed ommatidia (containing a single R7 at their centre). The R7 cells in these ommatidia are invariably pigmented (indicating the presence of RV12.hs2sev) and demonstrate the cell-autonomous rescue of sev14 in the R7 precursor by activated R.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
RV12.hs2sev
Rap1V12.hs2sev
Name Synonyms
Secondary FlyBase IDs
    References (2)