FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\bratUAS.Tag:MYC
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General Information
Symbol
Dmel\bratUAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0276849
Feature type
allele
Associated gene
Dmel\brat
Associated Insertion(s)
Carried in Construct
P{UAS-brat.myc}
Also Known As
UAS-brat-myc
Key Links
Transgenic product class
wild_type
(Xiao et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Xiao et al., 2012)
Mutagen
in vitro construct
(Xiao et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-brat.myc}
Cytology
Description

UASt regulatory sequences drive expression of brat which is tagged with Tag:MYC.

(Xiao et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
brat
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  brain cancer
      modeled by bratchs
      (Loewen et al., 2018)
      ameliorates  neurodegenerative disease
      modeled by bratchs
      (Loewen et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of bratScer\UAS.T:Hsap\MYC suppresses the formation of supernumerary type II neuroblasts which is seen in type II neuroblast lineage clones expressing kluScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Act5C.PP.

      (Xiao et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      bratUAS.Tag:MYC/Scer\GAL4wor.PA rescues brat11/Df(2L)Exel8040

      (Komori et al., 2014)

      bratUAS.Tag:MYC/Scer\GAL4VP16.nanos.UTR rescues Df(2L)Exel8040/bratfs1

      (Komori et al., 2014)
      Comments

      Expression of bratScer\UAS.T:Hsap\MYC under the control of Scer\GAL4wor.PA suppresses the supernumerary type II neuroblast phenotype seen in brat11/Df(2L)Exel8040 larval brains.

      Expression of bratScer\UAS.T:Hsap\MYC under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 rescues the defects in abdominal segmentation seen in bratfs1/Df(2L)Exel8040 embryos.

      (Komori et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      bratScer\UAS.T:Hsap\MYC
      bratUAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (6)