FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ppk23Δ8.284
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General Information
Symbol
Dmel\ppk23Δ8.284
Species
D. melanogaster
Name
FlyBase ID
FBal0277047
Feature type
allele
Associated gene
Dmel\ppk23
Associated Insertion(s)
Carried in Construct
Also Known As
Δppk23
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Thistle et al., 2012)
Mutagen
FLPase
(Thistle et al., 2012)
Progenitor genotype
PBac{RB}Ankle2e03639
(Thistle et al., 2012)
P{XP}d04369
(Thistle et al., 2012)
Cytology
Description

FLP-mediated recombination between P{XP}d04369 and PBac{RB}l(1)G0222e03639 removes 8.284kb surrounding ppk23, including a 3' fragment of l(1)G0222.

(Thistle et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ppk23Δ8.284 mutant males show significantly lower courtship intensity as compared with wild type.

      (Hu et al., 2015)

      Homozygous ppk23Δ8.284 mutant larvae have significantly reduced preference for larval-treated substrate, compared to controls; attraction to the secreted larval fatty acids (Z)-5-tetradecanoic acid and (Z)-7-tetradecanoic acid is significantly reduced, compared to controls.

      (Mast et al., 2014)

      ppk23Δ8.284 males show vigorous courtship towards wild-type target males, as measured by the number of unilateral wing extensions. Moreover, when 6-9 ppk23Δ8.284 males are placed together in a chamber, they serially court each other, forming long chains in which males follow each other and produce courtship songs.

      ppk23Δ8.284 males lacking antennae show a complete loss of male-male courting.

      In a 30min trial, ppk23Δ8.284 males court females with reduced frequency and longer latency compared to controls, often with ppk23Δ8.284 males failing to court at all.

      ppk23Δ8.284 mutant flies explosed to oe[-] males (Scer\GAL4desat1.PB, Scer\GAL80ts.αTub84B/WScer\UAS.cZa) painted with 7T, 7P, or cVA, do not exhibit differences in courtship, whereas control males exhibit a reduction in courtship. Additionally, controls increase courtship to oe[-] females painted with 7,11-HD, 7,11-ND, or 7P, whereas ppk23Δ8.284 males show no change in behavior.

      (Thistle et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Introduction of ppk29Scer\UAS.cTa into ppk23Δ8.284 mutants under the control of Scer\GAL4ppk23.2.695 fails to suppress the courtship defects found in ppk23Δ8.284 mutants.

      (Thistle et al., 2012)

      In proboscis extension assays, ppk23Δ8.284 ppk29Δ double mutant flies show no significant defects in detection of sugars, bitter compounds, salt, or water.

      (Thistle et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      ppk23Δ8.284 is rescued by ppk23UAS.cTa/Scer\GAL4ppk23.2.695

      (Thistle et al., 2012)
      Partially rescued by

      ppk23Δ8.284 is partially rescued by Scer\GAL4GMR58F10/ppk23UAS.cTa

      (Mast et al., 2014)
      Comments

      Expression of ppk23Scer\UAS.cTa under the control of Scer\GAL4ppk23.2.695 rescues the male-male courtship and reduced female courtship found in ppk23Δ8.284 mutant males.

      (Thistle et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      ppk23Δ8.284
      ppk23Δ
      (Thistle et al., 2012, Thistle et al., 2012)
      Δppk23
      (Zhang et al., 2020, Lee et al., 2018, Hu et al., 2015, Shankar et al., 2015, Mast et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)