FlyBase Gene Report: Dmel\ppk23

General Information

Symbol

Dmel\ppk23

Species

D. melanogaster

Name

pickpocket 23

Annotation Symbol

CG8527

Feature Type

protein_coding_gene

FlyBase ID

FBgn0030844

Gene Model Status

Current

Stock Availability

19 publicly available

Gene Summary

pickpocket 23 (ppk23) encodes a gustatory-specific putative non-voltage gated cation channel that belongs to the Degenerin/Epithelial sodium channel (DEG/ENaC) family. It contributes to pheromone perception and male courtship behavior. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

16B4-16B4

Sequence location

X:17,566,552..17,569,228 [-]

Recombination map

1-57

RefSeq locus

NC_004354 REGION:17566552..17569228

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

contributes_to ligand-gated sodium channel activity

inferred from biological aspect of ancestor with PANTHER:PTN000189658

(GO Reference Genome Project, 2011-)

enables ligand-gated sodium channel activity

inferred by curator from GO:0043695

(Liu et al., 2020)

enables sodium channel activity

inferred from electronic annotation with InterPro:IPR001873

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with MGI:MGI:101782

(Gene Ontology Curators, 2002-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in detection of pheromone

inferred from genetic interaction with FLYBASE:ppk29; FB:FBgn0034965,FLYBASE:ppk25; FB:FBgn0053349

(Liu et al., 2020)

acts_upstream_of_positive_effect male courtship behavior

inferred from genetic interaction with FLYBASE:ppk29; FB:FBgn0034965,FLYBASE:ppk25; FB:FBgn0053349

(Liu et al., 2020)

involved_in male courtship behavior

inferred from mutant phenotype

(Hu et al., 2015, Lu et al., 2012, Toda et al., 2012)

involved_in response to pheromone

inferred from mutant phenotype

(Lu et al., 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in sodium ion transmembrane transport

inferred from biological aspect of ancestor with PANTHER:PTN000189658

(GO Reference Genome Project, 2011-)

involved_in sodium ion transport

inferred from electronic annotation with InterPro:IPR001873

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with MGI:MGI:101782

(Gene Ontology Curators, 2002-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR001873

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with MGI:MGI:101782

(Gene Ontology Curators, 2002-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000189658

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

PICKPOCKET ION CHANNELS

Protein Family (UniProt)

Protein Signatures (InterPro)

Epithelial sodium channel

Summaries

Gene Snapshot

Gene Group (FlyBase)

PICKPOCKET ION CHANNELS -: The degenerin (DEG)/epithial Na⁺ channel (ENaC) gene family, known as the pickpocket genes in Drosophila, encodes subunits of non-voltage gated, amiloride-sensitive cation channels. Channels may be formed by homo- or heteromeric arrangements of subunits. Each subunit has two transmembrane domains and a large cysteine-rich extracellular loop domain. They are functionally diverse, with roles in fluid and salt absorbance, mechanosensation and chemosensation. (Adapted from FBrf0220901 and FBrf0159284).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\ppk23 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A8JV41)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.43

Gene model reviewed during 5.54

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

ppk23-RA

FBtr0074491

NM_132992

1527

477

ppk23-RB

FBtr0100574

NM_001014749

1602

502

ppk23-RC

FBtr0112998

NM_001103541

1959

591

ppk23-RD

FBtr0329827

NM_001272717

2092

566

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

ppk23-PA

FBpp0074265

55.5

477

6.75

FBpp0100029

58.3

502

6.92

FBpp0111911

68.6

591

7.36

FBpp0302876

65.7

566

7.21

M9PHF4

NP_001259646

AGB95488

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Epithelial sodium channel

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ppk23 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

ppk23_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.33

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

labellar taste bristle chemosensory neuron | subset

(Thistle et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

leg

Comment: legs and wings assayed in same sample.

(Lu et al., 2012)

wing

Comment: legs and wings assayed in same sample.

(Lu et al., 2012)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

leg

Comment: legs and wings assayed in same sample.

(Lu et al., 2012)

wing

Comment: legs and wings assayed in same sample.

(Lu et al., 2012)

Additional Descriptive Data

RT-PCR analysis of ppk23 transcript expression shows that it is expressed in the legs and wings of both males and females, but at a higher level in the former.

(Lu et al., 2012)

ppk23 expression is detected in the gustatory receptor neurons in the proboscis. These neurons also express ppk29. There is no co-expression between ppk23 and ppk28 which labels the water-sensing neurons or Gr66a which labels the bitter-sensing neurons. The expression of ppk23 is very similar to that of ScerGAL4^ppk23.2.695.

(Thistle et al., 2012)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{ppk23-GAL4.2.6}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

prothoracic leg taste bristle chemosensory neuron

Comment: Stronger expression in males.

(Lu et al., 2012)

mesothoracic leg taste bristle chemosensory neuron

(Lu et al., 2012)

metathoracic leg taste bristle chemosensory neuron

(Lu et al., 2012)

chemosensory neuron | subset of wing margin bristle

(Lu et al., 2012)

adult ventral nerve cord | restricted

(Lu et al., 2012)

Reporter: P{ppk23-GAL4.2.336}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

high salt-sensing neuron of labellar taste bristle

(Li and Montell, 2021)

Reporter: P{ppk23-Gal4.2.695}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

gustatory receptor neuron of terminal organ dorsolateral group

(Mast et al., 2014)

gustatory receptor neuron of terminal organ distal group | subset

(Mast et al., 2014)

adult stage

gustatory receptor neuron | subset of adult prothoracic segment

(Clowney et al., 2015)

neuron | restricted of labellum

(Shankar et al., 2015)

neuron | restricted of prothoracic leg

(Shankar et al., 2015)

gustatory receptor neuron of the labellum | subset

(Lee et al., 2018)

calcium-sensing neuron of labellar S-type taste bristle

(Lee et al., 2018)

labellar taste bristle chemosensory neuron | subset

(Thistle et al., 2012)

leg taste bristle chemosensory neuron | subset

(Thistle et al., 2012)

adult gnathal ganglion | restricted

• neuron projection

(Thistle et al., 2012)

adult ventral nerve cord | restricted

• neuron projection

(Thistle et al., 2012)

adult female pheromone-sensing neuron of leg

(Kallman et al., 2015)

adult male pheromone-sensing neuron of leg

(Kallman et al., 2015)

Reporter: P{ppk23-lexA.D}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult pheromone-sensing neuron

(Kim et al., 2017)

high salt-sensing neuron of labellar taste bristle

(Li and Montell, 2021)

adult female pheromone-sensing neuron of leg

(Kallman et al., 2015)

adult male pheromone-sensing neuron of leg

(Kallman et al., 2015)

Reporter: P{ppk25-GAL4.S}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

prothoracic leg

(Starostina et al., 2012)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\ppk23 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\ppk23

View exonic expression by tissue for Dmel\ppk23

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32731/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030844

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030844

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030844

Flygut - An atlas of the Drosophila adult midgut

FBgn0030844

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of ppk23

Transgenic constructs containing regulatory region of ppk23

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 18 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

ppk23^c03836

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

ppk23^KK110717

viable, with Scer\GAL4^Mef2.PR

ppk23^GD3413

viable, with Scer\GAL4^pnr-MD237

ppk23^GD3413

Sterility

Allele

fertile

ppk23^c03836

Other Phenotypes

Allele

abnormal chemosensory behavior | adult stage

ppk23^Δ8.284

abnormal chemosensory behavior | larval stage | recessive

ppk23^Δ8.284

abnormal courtship behavior

ppk23^Δ8.284

abnormal courtship behavior | male

abnormal locomotor behavior | larval stage | recessive

ppk23^Δ8.284

abnormal mating behavior | male

abnormal neurophysiology | adult stage

ppk23^Δ8.284

Phenotype manifest in

Allele

adult olfactory receptor neuron Or47b

ppk23^Δ8.284

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (9)

Hsap\ASIC1

4 of 14

Yes

Hsap\ASIC2

4 of 14

Yes

Hsap\ASIC3

4 of 14

Yes

Hsap\ASIC4

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (8)

Rnor\Asic3

4 of 14

Yes

Rnor\Asic4

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Mus musculus (laboratory mouse) (8)

Mmus\Asic1

4 of 14

Yes

Mmus\Asic2

4 of 14

Yes

Mmus\Asic3

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Xenopus tropicalis (Western clawed frog) (13)

Xtro\asic4

2 of 13

Yes

Xtro\LOC100497753

2 of 13

Yes

Xtro\LOC101731449

2 of 13

Yes

Xtro\scnn1b

2 of 13

Yes

Xtro\asic1

1 of 13

Xtro\asic2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\scnn1g

1 of 13

Danio rerio (Zebrafish) (7)

Drer\asic4a

4 of 14

Yes

Drer\asic4b

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (28)

Cele\acd-1

5 of 14

Yes

Cele\acd-2

5 of 14

Yes

Cele\acd-4

5 of 14

Yes

Cele\acd-5

5 of 14

Yes

Cele\delm-1

5 of 14

Yes

Cele\delm-2

5 of 14

Yes

Cele\flr-1

5 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Cele\del-9

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (24)

Agam\AgaP_AGAP000840

12 of 12

Yes

4 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:ppk23. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (31)

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

ppk

4 of 13

rpk

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ASIC1; acid sensing ion channel subunit 1

4 of 14

602866

ASIC2; acid sensing ion channel subunit 2

4 of 14

601784

ASIC3; acid sensing ion channel subunit 3

4 of 14

611741

ASIC4; acid sensing ion channel subunit family member 4

4 of 14

606715

ASIC5; acid sensing ion channel subunit family member 5

3 of 14

616693

SCNN1A; sodium channel epithelial 1 subunit alpha

3 of 14

600228

SCNN1B; sodium channel epithelial 1 subunit beta

3 of 14

600760

SCNN1D; sodium channel epithelial 1 subunit delta

3 of 14

601328

SCNN1G; sodium channel epithelial 1 subunit gamma

3 of 14

600761

bronchiectasis 3

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59059

DroID - A comprehensive database of gene and protein interactions.

FBgn0030844

MIST (protein-protein) - An integrated Molecular Interaction Database

32731

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Stimuli-sensing channels

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-57

Cytogenetic map

16B4-16B4

Sequence location

X:17,566,552..17,569,228 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

16B4-16B4

Limits computationally determined from genome sequence between P{EP}baz^EP1446 and P{EP}EP1464

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

16B4-16B6

(Welsh, 2003.1.16)

Experimentally Determined Recombination Data

Location

1-57

(FlyBase, 2016)

1-57.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (19)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

33300

w^* P{EP}ppk23^G17320

74106

w¹¹¹⁸; P{VT063314-p65.AD}attP40

600884

w¹¹¹⁸; P{VT063311-p65.AD}attP40

74725

w¹¹¹⁸; P{VT063314-GAL4.DBD}attP2

75373

w¹¹¹⁸; P{VT063311-GAL4.DBD}attP2

Korea

13606

P{VT063314-GAL4}attP2

15491

P{VT063311-GAL4}attP2

16678

P{VT063311-lexA}attP40

NIG-Fly

8527R-3

P{NIG.8527R}3

HMJ22035

y¹ v¹; P{TRiP.HMJ22035}attP40/CyO

VDRC

v106873

P{KK110717}VIE-260B

v39581

w¹¹¹⁸; P{GD3413}v39581/TM3

More stocks available...

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (15)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

IP13962

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0030844

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0030844

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Source for identity of ppk23 CG8527 was sequence comparison ( date:030311 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: ppk23 CG8527

(FlyBase, 1996-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG8527

(National Institute of Genetics Fly Stocks, 2023-, Hosono et al., 2015, Zelle et al., 2013, Tsubouchi et al., 2012, Jiang et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Giot et al., 2003)

PPK-23

(Sheng et al., 2017)

PPK23

(Liu et al., 2003, Welsh, 2003.1.16)

Ppk23

(Montell, 2021, Guo et al., 2020, Auer and Benton, 2016, Hoopfer, 2016, Fan et al., 2013, Pikielny, 2012)

ppk-23

(Ishimoto and Kamikouchi, 2021)

ppk23

(Chen et al., 2025, Asefa et al., 2024, Kaulich et al., 2023, Wu et al., 2022, Bianchi, 2021, Cho et al., 2021, Devineni and Scaplen, 2021, Goodwin and Hobert, 2021, Latorre-Estivalis et al., 2021, Spierer et al., 2021, Anholt et al., 2020, Chen and Dahanukar, 2020, Guo et al., 2020, Liu et al., 2020, Miller et al., 2020, Sato and Yamamoto, 2020, Sato et al., 2020, He et al., 2019, Narasimha et al., 2019, Billeter and Wolfner, 2018, Lin et al., 2018, Seeholzer et al., 2018, Stefana et al., 2017, Hu et al., 2015, Kohl et al., 2015, Lin et al., 2015, Shankar et al., 2015, Gendron et al., 2014, Vijayan et al., 2014, Yamamoto et al., 2014, Billeter and Levine, 2013, Fan et al., 2013, Fernández and Kravitz, 2013, Manoli et al., 2013, Pavlou and Goodwin, 2013, Yamamoto and Koganezawa, 2013, Zelle et al., 2013, Ben-Shahar, 2012.2.9, Japanese National Institute of Genetics, 2012.5.21, Lu et al., 2012, Thistle et al., 2012, Thistle et al., 2012, Toda et al., 2012, Tsubouchi et al., 2012, Ben-Shahar, 2011, Jungreis, 2011.11.18, Chen et al., 2010, Pospisilik et al., 2010)

Name Synonyms

pickpocket 23

(Shafer, 2025, Zelle et al., 2013, Ben-Shahar, 2012.2.9, Tsubouchi et al., 2012, Edwards et al., 2009)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 44 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32731

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A8JV41

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A8JV41

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32731/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030844

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030844

FlyMine - An integrated database for Drosophila genomics

FBgn0030844

InterPro - A database of protein families, domains and functional sites

Epithelial sodium channel

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8527

MARRVEL_MODEL - MARRVEL (model organism gene)

32731

Linkouts

BioGRID - A database of protein and genetic interactions.

59059

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0030844

DroID - A comprehensive database of gene and protein interactions.

FBgn0030844

DRSC - Results frm RNAi screens

FBgn0030844

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

ppk23_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030844

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0030844

Flygut - An atlas of the Drosophila adult midgut

FBgn0030844

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0030844

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012362

MIST (protein-protein) - An integrated Molecular Interaction Database

32731

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Stimuli-sensing channels

References (109)

The following external sites may use different assemblies or annotations than FlyBase.

-0.33

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