FlyBase Gene Report: Dmel\rpk

General Information

Symbol

Dmel\rpk

Species

D. melanogaster

Name

ripped pocket

Annotation Symbol

CG1058

Feature Type

protein_coding_gene

FlyBase ID

FBgn0022981

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Summary

ripped pocket (rpk) encodes a sodium channel in the Degenerin/Epithelial Sodium Channel/Acid Sensing Ion Channel (Deg/ENaC/ASIC) family. Expression of rpk in the larval multidendritic neurons is required for the detection of gentle touch stimuli. [Date last reviewed: 2018-10-04] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

dGNaC1

Key Links

Genomic Location

Cytogenetic map

82C5-82C5

Sequence location

3R:4,645,981..4,648,884 [+]

Recombination map

3-47.1

RefSeq locus

NT_033777 REGION:4645981..4648884

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

contributes_to ligand-gated sodium channel activity

inferred from biological aspect of ancestor with PANTHER:PTN000189658

(GO Reference Genome Project, 2011-)

enables sodium channel activity

inferred from electronic annotation with InterPro:IPR001873, InterPro:IPR020903

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with MGI:MGI:101782

(Gene Ontology Curators, 2002-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in detection of mechanical stimulus involved in sensory perception of pain

inferred from expression pattern

(Zelle et al., 2013)

involved_in sensory perception of touch

inferred from mutant phenotype

(Tsubouchi et al., 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in sodium ion transmembrane transport

inferred from biological aspect of ancestor with PANTHER:PTN000189658

(GO Reference Genome Project, 2011-)

involved_in sodium ion transport

inferred from electronic annotation with InterPro:IPR001873, InterPro:IPR020903

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with MGI:MGI:101782

(Gene Ontology Curators, 2002-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in axon

inferred from direct assay

(Tsubouchi et al., 2012)

located_in dendrite

inferred from direct assay

(Tsubouchi et al., 2012)

located_in neuronal cell body

inferred from direct assay

(Tsubouchi et al., 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR001873, InterPro:IPR020903

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with MGI:MGI:101782

(Gene Ontology Curators, 2002-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000189658

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

PICKPOCKET ION CHANNELS

MECHANOSENSITIVE PICKPOCKET ION CHANNELS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

PICKPOCKET ION CHANNELS -: The degenerin (DEG)/epithial Na⁺ channel (ENaC) gene family, known as the pickpocket genes in Drosophila, encodes subunits of non-voltage gated, amiloride-sensitive cation channels. Channels may be formed by homo- or heteromeric arrangements of subunits. Each subunit has two transmembrane domains and a large cysteine-rich extracellular loop domain. They are functionally diverse, with roles in fluid and salt absorbance, mechanosensation and chemosensation. (Adapted from FBrf0220901 and FBrf0159284).
MECHANOSENSITIVE PICKPOCKET ION CHANNELS -: Pickpocket (PPK) ion channels are transmembrane sodium ion channels. Some members of the PPK family have been shown to be gated by mechanical stimulation (Adapted from FBrf0248531.)

Summary (Interactive Fly)

Ripped pocket leads to defects in force generation during dorsal closure via failure of actomyosin structures - functions in the PNS to regulate behavioral responses to touch and in the formation of the actin-rich sensory filopodia

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\rpk for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A0B4K691)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

rpk-RA

FBtr0078859

NM_079501

2518

562

rpk-RB

FBtr0305313

NM_001259980

2536

568

Additional Transcript Data and Comments

Reported size (kB)

3.4 (northern blot)

(Adams et al., 1998)

3.2, 2.3, 1.738 (longest cDNA)

(Darboux et al., 1998)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

rpk-PA

FBpp0078499

64.8

562

6.21

FBpp0293856

65.4

568

6.21

A0A0B4K691

NP_001246909

AFH06228

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

562 (aa); 65 (kD predicted)

(Adams et al., 1998)

562 (aa)

(Darboux et al., 1998)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\rpk using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.23

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 8

(Darboux et al., 1998)

larval stage

wing disc

(Organista et al., 2015)

adult stage | male

seminal vesicle

(Darboux et al., 1998)

spermatogenesis & adult stage

primary spermatocyte cyst

(Darboux et al., 1998)

oogenesis stage S5 -- S14

(Darboux et al., 1998)

oogenesis stage S10

nurse cell

(Darboux et al., 1998)

follicle cell

(Darboux et al., 1998)

oocyte

(Darboux et al., 1998)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage & adult stage

(Adams et al., 1998)

embryonic stage 1 -- 6

Comment: reference states 0-3 hr AEL

(Adams et al., 1998)

embryonic stage 1 -- 9

Comment: reference states 0-4 hr AEL

(Darboux et al., 1998)

adult stage

gonad

(Darboux et al., 1998)

ovary

(Darboux et al., 1998)

Additional Descriptive Data

rpk transcripts are detected in 0-3 hr embryos and in adult flies.

(Adams et al., 1998)

rpk transcripts are detected in 0-4 hr embryos, and in gonads.

(Darboux et al., 1998)

rpk transcript is detected in gonads. In females, expression is detected in stem cells, oogonia, and early cysts. Expression is low at stage S5, but high at stage S10, and is detected in nurse cells, oocytes, and follicle cells. rpk transcript is distributed uniformly in syncytial and cellular blastoderm embryos, declines at early gastrulation, and subsequently disappears. In males, expression is detected in cysts containing primary spermatocytes or cells entering meiosis, and in seminal vesicles.

(Darboux et al., 1998)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in axon

inferred from direct assay

(Tsubouchi et al., 2012)

located_in dendrite

inferred from direct assay

(Tsubouchi et al., 2012)

located_in neuronal cell body

inferred from direct assay

(Tsubouchi et al., 2012)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\rpk in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\rpk

View exonic expression by tissue for Dmel\rpk

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40580/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0022981

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0022981

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0022981

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1058

Flygut - An atlas of the Drosophila adult midgut

FBgn0022981

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of rpk

Transgenic constructs containing regulatory region of rpk

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)rpk-Karyβ3

(Tsubouchi et al., 2012)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

rpk^GD3621

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

rpk^GD3621

viable, with Scer\GAL4^tin.CΔ4

rpk^GD3621

Other Phenotypes

Allele

abnormal flight, with Scer\GAL4^Mef2.PR

rpk^GD3621

abnormal neuroanatomy | larval stage, with Dcr-2^UAS.cDa, Scer\GAL4^1003.3

rpk^GD3621

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

rpk^GD3621

abnormal size | adult stage, with Scer\GAL4^nub.PU

rpk^GD3621

abnormal touch response, with Scer\GAL4^109(2)80

rpk^GD3621

abnormal touch response, with Scer\GAL4^1003.3

rpk^GD3621

abnormal touch response | larval stage, with Dcr-2^UAS.cDa, Scer\GAL4^1003.3

rpk^GD3621

abnormal touch response | larval stage, with Karyβ3^{+tCH321-22I15}

rpk^Δ

some die during pupal stage, with Scer\GAL4^pnr-MD237

rpk^GD3621

Phenotype manifest in

Allele

larval dorsal multidendritic neuron ddaA | larval stage, with Dcr-2^UAS.cDa, Scer\GAL4^1003.3

rpk^GD3621

plasma membrane | oogenesis | conditional, with Scer\GAL4^{VP16.mat.αTub67C}

rpk^HMS01973

sensory dendrite | larval stage, with Dcr-2^UAS.cDa, Scer\GAL4^1003.3

rpk^GD3621

unfertilized egg | oogenesis | conditional, with Scer\GAL4^{VP16.mat.αTub67C}

rpk^HMS01973

wing, with Scer\GAL4^nub.PU

rpk^GD3621

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (9)

Hsap\ASIC1

8 of 14

Yes

Hsap\ASIC2

8 of 14

Yes

Hsap\ASIC3

8 of 14

Yes

Hsap\ASIC4

8 of 14

Yes

Hsap\ASIC5

8 of 14

Yes

5 of 14

5 of 14

4 of 14

4 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (8)

Rnor\Asic4

8 of 14

Yes

Rnor\Asic5

8 of 14

Yes

7 of 14

7 of 14

7 of 14

6 of 14

6 of 14

5 of 14

Mus musculus (laboratory mouse) (8)

Mmus\Asic1

9 of 14

Yes

Mmus\Asic2

9 of 14

Yes

Mmus\Asic5

9 of 14

Yes

Mmus\Asic3

8 of 14

Mmus\Asic4

8 of 14

Yes

Mmus\Scnn1b

7 of 14

Mmus\Scnn1g

7 of 14

Mmus\Scnn1a

5 of 14

Xenopus tropicalis (Western clawed frog) (16)

Xtro\asic4

6 of 13

Yes

Xtro\LOC100497753

6 of 13

Yes

Xtro\scnn1a

5 of 13

Yes

Xtro\scnn1d

5 of 13

Yes

Xtro\LOC101731449

4 of 13

Xtro\LOC116411522

4 of 13

Yes

Xtro\LOC116411523

4 of 13

Yes

Xtro\scnn1b

4 of 13

Xtro\scnn1g

3 of 13

Xtro\trim13

3 of 13

Yes

Xtro\asic1

1 of 13

Xtro\asic2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (7)

Drer\asic4a

9 of 14

Yes

Drer\asic4b

9 of 14

Yes

8 of 14

8 of 14

7 of 14

7 of 14

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (28)

Cele\acd-1

7 of 14

Yes

Cele\acd-2

7 of 14

Yes

Cele\acd-4

7 of 14

Yes

Cele\acd-5

7 of 14

Yes

Cele\delm-1

7 of 14

Yes

Cele\delm-2

7 of 14

Yes

Cele\asic-1

6 of 14

Cele\asic-2

6 of 14

Cele\deg-1

6 of 14

Yes

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

Yes

Cele\acd-3

5 of 14

Yes

Cele\del-10

5 of 14

Yes

Cele\unc-8

5 of 14

Yes

Cele\del-5

3 of 14

Yes

Cele\del-9

3 of 14

Yes

3 of 14

3 of 14

3 of 14

2 of 14

Yes

Cele\del-6

2 of 14

Yes

Cele\egas-1

2 of 14

Cele\F58G6.8

2 of 14

Cele\del-7

1 of 14

Anopheles gambiae (African malaria mosquito) (24)

Agam\AgaP_AGAP012279

7 of 12

Yes

Agam\AgaP_AGAP011103

6 of 12

Yes

Agam\AgaP_AGAP011433

6 of 12

Yes

Agam\AgaP_AGAP011610

6 of 12

Agam\AgaP_AGAP011611

6 of 12

Yes

Agam\AgaP_AGAP001602

5 of 12

Agam\AgaP_AGAP006703

5 of 12

Yes

Agam\AgaP_AGAP006704

5 of 12

Yes

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:rpk. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (31)

11 of 13

11 of 13

11 of 13

11 of 13

10 of 13

ppk

10 of 13

9 of 13

8 of 13

7 of 13

7 of 13

6 of 13

6 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ASIC1; acid sensing ion channel subunit 1

8 of 14

602866

ASIC2; acid sensing ion channel subunit 2

8 of 14

601784

ASIC3; acid sensing ion channel subunit 3

8 of 14

611741

ASIC4; acid sensing ion channel subunit family member 4

8 of 14

606715

ASIC5; acid sensing ion channel subunit family member 5

8 of 14

616693

SCNN1B; sodium channel epithelial 1 subunit beta

5 of 14

600760

SCNN1G; sodium channel epithelial 1 subunit gamma

5 of 14

600761

bronchiectasis 3

SCNN1A; sodium channel epithelial 1 subunit alpha

4 of 14

600228

SCNN1D; sodium channel epithelial 1 subunit delta

4 of 14

601328

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Smox

suppressible

rpk

(Hevia et al., 2017)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0022981

MIST (protein-protein) - An integrated Molecular Interaction Database

40580

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Stimuli-sensing channels

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47.1

Cytogenetic map

82C5-82C5

Sequence location

3R:4,645,981..4,648,884 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

82C5-82C5

Limits computationally determined from genome sequence between P{PZ}l(3)02733⁰²⁷³³ and P{EP}EP974

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

82C-82D

(determined by in situ hybridisation)

(Darboux et al., 1998)

Experimentally Determined Recombination Data

Location

3-47.1

(FlyBase, 2016)

3-44.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

25847

y¹ v¹; P{TRiP.JF01868}attP2

82869

y¹ v¹; P{TKO.GS05098}attP40

39053

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01973}attP40

NIG-Fly

1058R-1

P{NIG.1058R}1

HMJ22133

y¹ v¹; P{TRiP.HMJ22133}attP40/CyO

VDRC

v105463

P{KK104901}VIE-260B

v8549

w¹¹¹⁸; P{GD3621}v8549

Genomic Clones (9)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (93)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0022981

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0022981

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

rpk has been cloned and characterised.

(Adams et al., 1998)

rpk has been cloned and sequenced.

(Darboux et al., 1998)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG1058

(Hevia et al., 2017, Zelle et al., 2013, Tsubouchi et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15)

GNaC1

RPK

(Bianchi, 2021, Hehlert et al., 2021, Adams et al., 1997)

Rpk

(Asefa et al., 2024, Emmons-Bell and Hariharan, 2021, Guo et al., 2020, George et al., 2019)

dGNaC1

(Darboux et al., 1998, Darboux et al., 1998, Darboux et al., 1998, Lingueglia, 1998.1.15, Waldmann and Lazdunski, 1998)

ppk2

(Zelle et al., 2013)

rpk

(Gowda et al., 2021, Roy Choudhury et al., 2021, Crava et al., 2020, Schotthöfer and Bohrmann, 2020, Yan et al., 2018, Transgenic RNAi Project members, 2017-, Organista et al., 2015, Guo et al., 2014, Hunter et al., 2014, Sartain and Wolfner, 2013, Zelle et al., 2013, Ben-Shahar, 2012.2.9, Japanese National Institute of Genetics, 2012.5.21, Tsubouchi et al., 2012, Tsubouchi et al., 2012, Ben-Shahar, 2011, Horner and Wolfner, 2008, Chintapalli et al., 2007)

Name Synonyms

gonad-specific amiloride-sensitive sodium channel 1

ripped pocket

(Zelle et al., 2013, Ben-Shahar, 2012.2.9, Tsubouchi et al., 2012, Tsubouchi et al., 2012, Horner and Wolfner, 2008, Anderson et al., 1997)

ripped-pocket

(York-Andersen et al., 2021)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40580

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A0B4K691

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A0B4K691

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40580/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0022981

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0022981

FlyMine - An integrated database for Drosophila genomics

FBgn0022981

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1058

MARRVEL_MODEL - MARRVEL (model organism gene)

40580

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0022981

DroID - A comprehensive database of gene and protein interactions.

FBgn0022981

DRSC - Results frm RNAi screens

FBgn0022981

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0022981

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0022981

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1058

Flygut - An atlas of the Drosophila adult midgut

FBgn0022981

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

40580

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Stimuli-sensing channels

References (67)

The following external sites may use different assemblies or annotations than FlyBase.

0.23

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