FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dana\KhcUAS.RR
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General Information
Symbol
Dana\KhcUAS.RR
Species
D. ananassae
Name
FlyBase ID
FBal0277315
Feature type
allele
Associated gene
Dana\Khc
Associated Insertion(s)
Carried in Construct
M{UAS-Dana\Khc.RR}
Transgenic product class
wild_type
(Schmidt et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Schmidt et al., 2012)
Mutagen
in vitro construct
(Schmidt et al., 2012)
Progenitor genotype
Carried in construct
M{UAS-Dana\Khc.RR}
Cytology
Description

UAS regulatory sequences drive expression of the full-length Dana\Khc coding sequence. Two stretches of perfect homology (21 and 17 nucleotides long) that is targeted by an RNAi construct against Khc (KhcGD12278) have been changed by site-directed mutagenesis to improve rescue ability.

(Schmidt et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Dana\Khc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Dana\KhcRNAi-res.Scer\UAS rescues the locomotor defects seen in adults and larvae expressing KhcGD12278 under the simultaneous control of both Scer\GAL4repo.PL and Scer\GAL4repo.

      Expression of Dana\KhcRNAi-res.Scer\UAS under the control of Scer\GAL4da.G32 rescues the lethality of Khc8/Df(2R)Jp6 flies.

      Co-expression of Dana\KhcRNAi-res.Scer\UAS rescues the reduced excitatory junction potential amplitude seen in third instar larvae expressing KhcGD12278 under the control of Scer\GAL4Gli-J29-Gal4.

      (Schmidt et al., 2012)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Dana\KhcRNAi-res.Scer\UAS
      Dana\KhcRNAi-res.UAS
      Dana\KhcUAS.RR
      khcana
      (Schmidt et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)