FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\toyRNAi.UAS.cWa
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General Information
Symbol
Dmel\toyRNAi.UAS.cWa
Species
D. melanogaster
Name
FlyBase ID
FBal0277650
Feature type
allele
Associated gene
Dmel\toy
Associated Insertion(s)
Carried in Construct
P{UAS-mi-toy-mi-cut}
Key Links
Transgenic product class
RNAi_reagent
(Wang and Sun, 2012)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Wang and Sun, 2012)
Mutagen
in vitro construct
(Wang and Sun, 2012)
Progenitor genotype
Carried in construct
P{UAS-mi-toy-mi-cut}
Cytology
Description

UAS regulatory sequences drive expression of a microRNA that contains a 22bp fragment which is complementary to toy coding regions.

(Wang and Sun, 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
toy
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Animals expressing P{UAS-mi-toy-mi-cut} (ctmiRNA.Scer\UAS.cWa and toymiRNA.Scer\UAS.cWa) under the control of Scer\GAL4mirr-DE all die at the pharate stage when raised at 25[o]C. Most head structures are lost, with the labellum, which is derived from the labial disc, remaining. When raised at 17[o]C the adults have small eyes but normal antenna and palp.

      Expression of P{UAS-mi-toy-mi-cut} (ctmiRNA.Scer\UAS.cWa and toymiRNA.Scer\UAS.cWa) under the control of Scer\GAL4mirr-DE causes a reduction in the size of second instar larval eye discs. Neural differentiation and disc size are significantly repressed in the third instar larval eye disc.

      (Wang and Sun, 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      toyRNAi.UAS.cWa
      toymiRNA.Scer\UAS.cWa
      toymiRNA.UAS.cWa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)