FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sarm+tOa
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General Information
Symbol
Dmel\Sarm+tOa
Species
D. melanogaster
Name
FlyBase ID
FBal0277681
Feature type
allele
Associated gene
Dmel\Sarm
Associated Insertion(s)
Carried in Construct
P{Sarm.+tOa}
Key Links
Transgenic product class
genomic_DNA
(Osterloh et al., 2012)
wild_type
(Osterloh et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Osterloh et al., 2012)
wild_type
(Osterloh et al., 2012)
Mutagen
in vitro construct
(Osterloh et al., 2012)
Progenitor genotype
Carried in construct
P{Sarm.+tOa}
Cytology
Description

Genomic BAC clone containing Ect4.

(Osterloh et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
Sarm
Encoded product / tool
Sarm
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  neurodegenerative disease
      CEA
      (Osterloh et al., 2012)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Sarm+tOa rescues Sarm896

      (Neukomm et al., 2017)

      Sarm+tOa rescues Sarm4314

      (Neukomm et al., 2017)

      Sarm+tOa rescues Df(3L)BSC795/Sarm896

      (Osterloh et al., 2012)

      Sarm+tOa rescues Sarm4621/Sarm896

      (Osterloh et al., 2012)
      Comments

      The axon death defect (severed axons remain intact for a full week after an axotomy, instead of being cleared away by day 5) characteristic for Ect44314 or Ect4896 mutants is rescued by combination with Ect4+tOa.

      (Neukomm et al., 2017)

      Ect4+tOa rescues the lethality and reverts the suppression of axonal degeneration after axon severing which is seen in Ect4896/Df(3L)BSC795 and Ect4896/Ect44621 animals.

      (Osterloh et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ect4+tOa
      Sarm+tOa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)