FB2026_02 , released June 18, 2026
Allele: Dmel\maf-SUAS.Tag:HA
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General Information
Symbol
Dmel\maf-SUAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0277751
Feature type
allele
Associated gene
Dmel\maf-S
Associated Insertion(s)
Carried in Construct
P{UAS-maf-S-HA}
Key Links
Transgenic product class
wild_type
(Barone et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Barone et al., 2011)
Mutagen
in vitro construct
(Barone et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-maf-S-HA}
Cytology
Description

UAS regulatory sequences are cloned upstream of maf-S coding sequences tagged at the C-terminal with three copies of Tag:HA.

(Barone et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
maf-S
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Hsap\SNCAUAS.cTa
      (Barone et al., 2011)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of maf-SScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4sev.EP does not result in a mutant eye phenotype.

      Expression of maf-SScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4arm.PS has no effect on survival after exposure to a semilethal dose of paraquat in young adults (10 days after hatching). However, at 40 days of age these animals show increased survival under these conditions compared to controls.

      Expression of maf-SScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4arm.PS significantly delays the loss of motor function with age and compared to wild type.

      Expression of maf-SScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Dot.PK ameliorates age-associated decline in heart performance.

      Expression of maf-SScer\UAS.T:Ivir\HA1 under the simultaneous control of both Scer\GAL4tin.cBa and Scer\GAL4Scer\UAS.cHa ameliorates age-associated decline in heart performance.

      (Rahman et al., 2013)

      Expression of maf-SScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ple.PF has no effect on locomotor performance.

      (Barone et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Scer\GAL4sev.EP/maf-SUAS.Tag:HA is an enhancer of visible phenotype of Scer\GAL4sev.EP, cncUAS.cSa

      (Rahman et al., 2013)
      Suppressor of
      NOT Suppressor of
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Scer\GAL4sev.EP/maf-SUAS.Tag:HA is an enhancer of eye phenotype of Scer\GAL4sev.EP, cncUAS.cSa

      (Rahman et al., 2013)
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of maf-SScer\UAS.T:Ivir\HA1 enhances the rough eye phenotype caused by expression of cncScer\UAS.cSa under the control of Scer\GAL4sev.EP.

      (Rahman et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of maf-SScer\UAS.T:Ivir\HA1 with Hsap\SNCAScer\UAS.cTa, both under the control of Scer\GAL4ple.PF, suppresses the age-dependent defects in negative geotaxis.

      Co-expression of maf-SScer\UAS.T:Ivir\HA1 in flies expressing Hsap\SNCAScer\UAS.cTa under the control of Scer\GAL4ple.PF, does not affect the number of PPL1 neurons in either young or old flies, but is sufficient to rescue the Hsap\SNCA-induced neurotoxicity in old flies.

      (Barone et al., 2011)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      maf-SScer\UAS.T:Ivir\HA1
      maf-SUAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (3)