FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fussDf(4)CORL
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General Information
Symbol
Dmel\fussDf(4)CORL
Species
D. melanogaster
Name
FlyBase ID
FBal0277890
Feature type
allele
Associated gene
Dmel\fuss
Associated Insertion(s)
PBac{WHr}CORL
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    PBac{WHr}CORL
    Caused by aberration
    Df(4)CORL
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    PBac{WHr}
    Regulatory region(s)
    UAS
    Also carries
    FRT
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  nervous system disease
        CEA
        (Dimitriadou et al., 2020)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Approximately 57% of CORLDf(4)CORL homozygotes die as larvae and an additional 22% die as pupae with 21% surviving to adulthood.

        CORLDf(4)CORL larvae exhibit poor growth, developmental delay, they wander away from food precociously and prematurely evert their anterior spiracles. CORLDf(4)CORL adults have greatly reduced lifespans and poor female fertility. CORLDf(4)CORL mutant mushroom bodies exhibit numerous structural defects such as shortened, misshapen or missing dorsal lobes, β-neurons that cross the midline and γ-lobe pruning defects.

        (Takaesu et al., 2012)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        fussDf(4)CORL is rescued by Scer\GAL4238Y/fussUAS.cTa

        (Takaesu et al., 2012)
        Comments

        Tissue specific expression of CORLScer\UAS.cTa under the control of Scer\GAL4238Y rescues the CORLDf(4)CORL mutant phenotype.

        (Takaesu et al., 2012)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        CORLDf(4)CORL
        Df(4)CORL
        (Takaesu et al., 2012)
        Df(4)dCORL
        (Dimitriadou et al., 2020)
        fussDf(4)CORL
        Name Synonyms
        Secondary FlyBase IDs
          References (2)