Deletion resulting from the imprecise excsion of P{SUPor-P}Atg8aKG07569, which removes the first 25 aa of Atg8a and the first 53 aa of BTBD9.
Imprecise excision of P{SUPor-P}Atg8aKG07569 removes the first 25 codons of Atg8a and the first 53 codons of BTBD9.
Atg8ad4 mutant adults do not display any obvious eye morphology defects or signs of degeneration.
Atg8ad4 homozygous mutants do not show any obvious defects in the morphology or structure of the adult thorax or loss of thoracic muscles.
Df(1)Atg8ad4 mutants are homozygous viable and fertile with no gross morphological or developmental abnormalities.
Atg8ad4/Atg8a[+], Hsap\FUSUAS.cIa, Scer\GAL4GMR.PS has visible | adult stage phenotype, suppressible by lncRNA:HsrωdsRNA.Sym.UAS, Scer\GAL4GMR.PS
Atg8ad4/Atg8a[+] is a non-enhancer of visible | adult stage phenotype of Hsap\FUSUAS.cIa, Scer\GAL4GMR.PS
Atg8ad4/Atg8ad4 is a suppressor of abnormal size | somatic clone | third instar larval stage phenotype of Atg13Δ81, Ras85DV12.UAS, Scer\GAL4Act.PU, scrib673
Atg8ad4/Atg8ad4 is a suppressor of neoplasia | somatic clone | third instar larval stage phenotype of Atg13Δ81, Ras85DV12.UAS, Scer\GAL4Act.PU, scrib673
Atg8ad4 is a suppressor of abnormal size phenotype of Scer\GAL4ptc-559.1, MycUAS.cZa
Atg8ad4 is a suppressor of visible phenotype of Scer\GAL4ptc-559.1, MycUAS.cZa
Atg8ad4/Atg8aUAS.GFP,mCherry, Scer\GAL4ptc-559.1 is a non-suppressor of abnormal size phenotype of Scer\GAL4ptc-559.1, MycUAS.cZa
Atg8ad4/Atg8aUAS.GFP,mCherry, Scer\GAL4ptc-559.1 is a non-suppressor of visible phenotype of Scer\GAL4ptc-559.1, MycUAS.cZa
Atg8ad4/Atg8a[+], Hsap\FUSUAS.cIa, Scer\GAL4GMR.PS has eye phenotype, suppressible by lncRNA:HsrωdsRNA.Sym.UAS, Scer\GAL4GMR.PS
Atg8ad4/Atg8a[+] is a non-enhancer of eye phenotype of Hsap\FUSUAS.cIa, Scer\GAL4GMR.PS
Atg8ad4 is a suppressor of 1st posterior cell phenotype of Scer\GAL4ptc-559.1, MycUAS.cZa
Atg8ad4 is a suppressor of wing basal cell 1 phenotype of Scer\GAL4ptc-559.1, MycUAS.cZa
Atg8ad4/Atg8aUAS.GFP,mCherry, Scer\GAL4ptc-559.1 is a non-suppressor of 1st posterior cell phenotype of Scer\GAL4ptc-559.1, MycUAS.cZa
Atg8ad4/Atg8aUAS.GFP,mCherry, Scer\GAL4ptc-559.1 is a non-suppressor of wing basal cell 1 phenotype of Scer\GAL4ptc-559.1, MycUAS.cZa
Atg8ad4/Atg8a[+], Hsap\MAPTUAS.GFP, Scer\GAL4shot-OK307, htt98E2/htt[+] has adult thorax phenotype
Atg8ad4/Atg8a[+], Hsap\MAPTUAS.GFP, Scer\GAL4shot-OK307, htt98E2/htt[+] has somatic muscle cell of thorax phenotype
Atg8ad4, Hsap\MAPTUAS.GFP, Scer\GAL4shot-OK307 has adult thorax phenotype
scrib673-homozygous, Ras85DV12.Scer\UAS-expressing tumors grow to significantly smaller sizes when grafted into the abdomen of Atg8ad4 homozygous adult hosts, as compared to control hosts.
The eye degeneration induced by Hsap\FUSScer\UAS.cIa expression (one copy) under Scer\GAL4GMR.PS is not exacerbated by combination with Atg8ad4/+ and the eye defects in the Scer\GAL4GMR.PS/Atg8ad4;Hsap\FUSScer\UAS.cIa/+ flies can still be rescued by expression of lncRNA:HsrωdsRNA.Sym.Scer\UAS (one copy).
Expression of Hsap\MAPTScer\UAS.T:Avic\GFP in Atg8ad4 heterozygous background does not produce any obvious phenotype in the adult thorax. However, when Hsap\MAPTScer\UAS.T:Avic\GFP is expressed in either htt98E2/+;Atg8ad4/+ double heterozygotes or Atg8ad4 homozygotes nearly all the adult flies have collapsed thoraces and display loss of skeletal thoracic muscles.