FlyBase Allele Report: Dmel\Vps13[HMS01715]

General Information

Symbol

Dmel\Vps13^HMS01715

Species

D. melanogaster

Name

FlyBase ID

FBal0278833

Feature type

allele

Associated gene

Dmel\Vps13

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01715}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS01715}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01715

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Parkinson's disease

modeled by Hsap\SNCA^UAS.cJa

(Jansen et al., 2017)

exacerbates Parkinson's disease 1

modeled by Hsap\SNCA^QUAS.cOa

(Olsen and Feany, 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

egg chamber, with Scer\GAL4^Act5C.PI

(Faber et al., 2020)

egg chamber, with Scer\GAL4^{VP16.nanos.UTR}

(Faber et al., 2020)

nucleus | ectopic | female, with Scer\GAL4^Act5C.PI

(Faber et al., 2020)

nucleus | ectopic | female, with Scer\GAL4^{VP16.nanos.UTR}

(Faber et al., 2020)

nurse cell, with Scer\GAL4^Act5C.PI

(Faber et al., 2020)

nurse cell, with Scer\GAL4^{VP16.nanos.UTR}

(Faber et al., 2020)

Detailed Description

Statement

Reference

The cell size in pupal (2hr after pupariation) midgut somatic clones expressing Vps13^HMS01715 under the control of Scer\GAL4^{Scer\FRT.Rnor\Cd2.Act5C} is comparable to control cells and the number of Atg8a puncta is also not significantly different.

(Anding et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Vps13^HMS01715, Scer\GAL4^ninaE.PT is an enhancer of abnormal neuroanatomy | adult stage | progressive phenotype of Hsap\SNCA^UAS.cJa, Scer\GAL4^ninaE.PT

(Jansen et al., 2017)

Phenotype Manifest In

Enhancer of

Statement

Reference

Vps13^HMS01715, Scer\GAL4^ninaE.PT is an enhancer of retina | adult stage | progressive phenotype of Hsap\SNCA^UAS.cJa, Scer\GAL4^ninaE.PT

(Jansen et al., 2017)

Vps13^HMS01715, Scer\GAL4^ninaE.PT is an enhancer of ommatidium | adult stage | progressive phenotype of Hsap\SNCA^UAS.cJa, Scer\GAL4^ninaE.PT

(Jansen et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The age-progressive retinal degeneration characteristic for flies expressing Hsap\SNCA^Scer\UAS.cJa under the control of Scer\GAL4^ninaE.PT is significantly enhanced by co-expression of Vps13^HMS01715.

(Jansen et al., 2017)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

38270

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01715}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Vps13^HMS01715

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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