FlyBase Allele Report: Dmel\JhI-21[HMS02271]

General Information

Symbol

Dmel\JhI-21^HMS02271

Species

D. melanogaster

Name

FlyBase ID

FBal0279273

Feature type

allele

Associated gene

Dmel\JhI-21

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS02271}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS02271}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS02271

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by Ras85D^V12.UAS, scrib¹

(Cong et al., 2021)

modeled by Rab5^LL00467, mir-ban^C.UAS.EGFP

(Cong et al., 2021)

ameliorates brain cancer

modeled by brat^KK113206

(Rebelo and Homem, 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased size | larval stage | somatic clone, with Scer\GAL4^Act5C.PI

(Cong et al., 2021)

Phenotype Manifest In

larval brain | larval stage | somatic clone, with Scer\GAL4^Act5C.PI

(Cong et al., 2021)

Detailed Description

Statement

Reference

Larval brain clones expressing JhI-21^HMS02271 under the control of Scer\GAL4^Act5C.PI are smaller than control clones.

(Cong et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

JhI-21^HMS02271, Scer\GAL4^Act5C.PI is a suppressor of neoplasia | somatic clone | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹

(Cong et al., 2021)

JhI-21^HMS02271, Scer\GAL4^Act5C.PI is a suppressor of lethal | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹

(Cong et al., 2021)

Other

Statement

Reference

JhI-21^HMS02271, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has visible | adult stage phenotype

(Cong et al., 2021)

Phenotype Manifest In

Suppressor of

Statement

Reference

JhI-21^HMS02271, Scer\GAL4^Act5C.PI is a suppressor of eye-antennal disc | somatic clone | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹

(Cong et al., 2021)

Other

Statement

Reference

JhI-21^HMS02271, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI, scrib¹ has eye phenotype

(Cong et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of JhI-21^HMS02271 suppresses tumorigenesis and lethality of eye-antennal disc clones a) both expressing Ras85D^V12.UAS under the control of Scer\GAL4^Act5C.PI and homozygous for scrib¹ or b) both expressing mir-ban^C.UAS.EGFP under the control of Scer\GAL4^Act5C.PI and homozygous for Rab5^LL00467. However, adults still exhibit an eye phenotype.

(Cong et al., 2021)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

41706

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02271}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

JhI-21^HMS02271

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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