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General Information
Symbol
Dmel\Klp10A24
Species
D. melanogaster
Name
FlyBase ID
FBal0280190
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Excision of the progenitor insertion, resulting in a 2742bp deletion that removes the 5' exon of Klp10A.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Hemizygotes arrest development prior to the third instar larval stage.

Oogenesis is completed and eggs are laid in females containing homozygous germline clones, however, the embryos fail to hatch. The mutant embryos show severe disorganisation of both the DNA and microtubules and no structures identifiable as pronuclear fusion or syncytial divisions are observed. Chromosomes are dispersed throughout the cytoplasm and microtubules form large asters surrounding the dispersed chromosomes.

Late-stage oocytes show defects in mutant females. Firstly, spindle microtubule bundles are much longer than in wild type. Secondly, ooplasmic microtubules are more numerous and longer than in wild type and are often arranged in a starburst pattern. Spindle disorganisation ranging from slight (bipolar with some fraying or bending) to extreme (long microtubule bundles with no apparent poles) is seen. The central spindle region is often missing in the mutant oocytes, resulting in two disconnected half spindles and multipolar spindles. The karyosome and spindle are not in proper contact. Bi-orientation of homologous chromosomes is defective.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

The defective microtubule organization observed in PatroninEY05252 mutant follicle cell clones is not improved upon combination with Klp10A24 in PatroninEY05252;Klp10A24 double mutant clones.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of Klp10AScer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4αTub84B.PL rescues the lethality of Klp10A24 hemizygotes.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (3)