FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\LanAC01-190
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General Information
Symbol
Dmel\LanAC01-190
Species
D. melanogaster
Name
FlyBase ID
FBal0280192
Feature type
allele
Associated gene
Dmel\LanA
Associated Insertion(s)
P{EP}LanAC01-190
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{EP}LanAC01-190
    Cytology
    Description

    Insertion of a P{EP} element in the 5'UTR of LanA, in the correct orientation for Scer\GAL4 mediated overexpression of LanA via the Scer\UAS sites in the P{EP} element.

    (Tsai et al., 2012)
    Allele components
    Component
    Use(s)
    Inserted element
    P{EP}
    Regulatory region(s)
    UAS
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Expression of LanAC01-190 under the control of Scer\GAL4C57 results in a reduction in size of the neuromuscular junction compared to controls.

        (Tsai et al., 2012)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Other
        Phenotype Manifest In
        Suppressor of
        Other
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        βInt-ν1/+ ; LanA9-32/LanAC01-190 third instar larvae show overgrowth of the neuromuscular junction.

        eag1 Sh21 double mutant third instar larvae show overgrowth of the neuromuscular junction. This overgrowth is significantly suppressed by expression of LanAC01-190 under the control of Scer\GAL4C57.

        The reduction in neuromuscular junction size seen in parats1 larvae at 29[o]C is suppressed by expression of LanAC01-190 under the control of Scer\GAL4C57.

        (Tsai et al., 2012)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments

        Expression of LanAC01-190 under the control of Scer\GAL4C57 fully suppresses the neuromuscular junction overgrowth seen in βInt-ν1/+ ; LanA9-32/LanAC01-190 third instar larvae, while expression under the control of Scer\GAL4elav.PU has no effect.

        (Tsai et al., 2012)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        LanAC01-190
        (Tsai et al., 2012)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)