FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\ihogGLC
Open Close
General Information
Symbol
Dmel\ihogGLC
Species
D. melanogaster
Name
FlyBase ID
FBal0280266
Feature type
allele
Associated gene
Dmel\ihog
Associated Insertion(s)
TI{TI}ihogGLC
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Zheng et al., 2010)
Mutagen
FLPase
(Zheng et al., 2010)
I-SceI
(Zheng et al., 2010)
ends-out gene targeting
(Zheng et al., 2010)
Progenitor genotype
Associated Insertion(s)
TI{TI}ihogGLC
Cytology
Description

A 2781bp genomic fragment containing the full ihog coding sequence has been replaced by a w+mW.hs marker. Adjacent genes remain intact.

(Zheng et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ihogGLC is found to be homozygous viable and fertile.

      (Zheng et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      ihogGLC has viable phenotype, suppressible by boiKO

      (Zheng et al., 2010)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Animals bred to homozygosity for both ihogGLC and boiKO die in early larval stages.

      Embryos derived from maternal germline clones of ihogGLC in a boiKO homozygous mutant background show a cuticle phenotype. Cuticle preparations from the mutant embryos reveal a fully penetrant phenotype in which naked cuticle normally present in the posterior of each segment fails to develop, resulting in a continuous lawn of poorly patterned denticles.

      (Zheng et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ihogGLC
      (Zheng et al., 2010)
      ihogGLC
      (Zheng et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)