FlyBase Allele Report: Dmel\fuss[UAS.C]

General Information

Symbol

Dmel\fuss^UAS.C

Species

D. melanogaster

Name

FlyBase ID

FBal0280475

Feature type

allele

Associated gene

Dmel\fuss

Associated Insertion(s)

Carried in Construct

P{UAS-fuss.C}

Key Links

Transgenic product class

cDNA

(Fischer et al., 2012)

wild_type

(Fischer et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Fischer et al., 2012)

wild_type

(Fischer et al., 2012)

Mutagen

in vitro construct

(Fischer et al., 2012)

Progenitor genotype

Carried in construct

P{UAS-fuss.C}

Cytology

Description

UASt drives expression of the full-length fuss cDNA (IP13014) corresponding to fuss-RC.

(Fischer et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

fuss

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size, with Scer\GAL4^A9

(Fischer et al., 2012)

Phenotype Manifest In

campaniform sensillum of dorsal radius, with Scer\GAL4^A9

(Fischer et al., 2012)

posterior crossvein, with Scer\GAL4^A9

(Fischer et al., 2012)

wing, with Scer\GAL4^A9

(Fischer et al., 2012)

wing vein L2, with Scer\GAL4^A9

(Fischer et al., 2012)

wing vein L2, with Scer\GAL4^nub-AC-62

(Fischer et al., 2012)

wing vein L5, with Scer\GAL4^A9

(Fischer et al., 2012)

wing vein L5, with Scer\GAL4^nub-AC-62

(Fischer et al., 2012)

Detailed Description

Statement

Reference

Expression of one copy of fuss^Scer\UAS.C with Scer\GAL4^A9 leads to vein truncations of L2, L5 and the posterior cross-vein at 100% penetrance, and results in a smaller wing size (75% vs controls). Expressing 2 copies of fuss^Scer\UAS.C causes wing size reduction up to 46% and a dramatic loss of vein and intervein tissue. Stronger phenotypes become manifest in unfolded wings.

Expression of one copy of fuss^Scer\UAS.C with Scer\GAL4^nub-AC-62 leads to vein truncations of L2, L5.

Expression of fuss^Scer\UAS.C with Scer\GAL4^A9 leads to loss of the campaniform sensilla on wing vein L3.

(Fischer et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

fuss^UAS.C, Scer\GAL4^A9 is a suppressor of abnormal size phenotype of Mad^UAS.cNa, Scer\GAL4^A9

(Fischer et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^A9/fuss^UAS.C is a suppressor | partially of wing vein | ectopic phenotype of Scer\GAL4^A9, sax^{Q263D.UAS.Tag:HA}

(Fischer et al., 2012)

Scer\GAL4^A9/fuss^UAS.C is a suppressor | partially of posterior crossvein phenotype of Scer\GAL4^A9, sax^{Q263D.UAS.Tag:HA}

(Fischer et al., 2012)

fuss^UAS.C, Scer\GAL4^A9 is a suppressor | partially of wing vein | ectopic phenotype of Mad^UAS.cNa, Scer\GAL4^A9

(Fischer et al., 2012)

fuss^UAS.C, Scer\GAL4^A9 is a suppressor | partially of wing vein | ectopic phenotype of Med^UAS.cSa, Scer\GAL4^A9

(Fischer et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Introducing one copy of fuss^Scer\UAS.C almost completely rescues the sax^{Q263D.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^A9 wing phenotype - vein formation is close to wild type.

Coexpression of fuss^Scer\UAS.C in a Mad^Scer\UAS.cNa, Scer\GAL4^A9 background restores not only the size of the wing, but leads to a notable amelioration of the vein-intervein patterning.

Coexpression of fuss^Scer\UAS.C restores wign shape and vein patterning of Med^Scer\UAS.cSa, Scer\GAL4^A9 wings to an almost wild type mode, with only slight failure of complete outgrowth of L5 and the posterior crossvein.

(Fischer et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

fuss^Scer\UAS.C

fuss^UAS.C

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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