FlyBase Allele Report: Dmel\CtBP[UAS.cSa]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\CtBP^UAS.cSa

General Information

Symbol

Dmel\CtBP^UAS.cSa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Stern

FlyBase ID

FBal0280477

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Also Known As

UAST-dCtBP

Key Links

Transgenic product class

(Stern et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Stern et al., 2007)

Mutagen

in vitro construct

(Stern et al., 2007)

Progenitor genotype

Carried in construct

Cytology

Description

UASt regulates expression of the 383 amino acid form of CtBP.

(Stern et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

anterior dorsocentral bristle, with Scer\GAL4^ap-md544

(Stern et al., 2007)

anterior dorsocentral bristle, with Scer\GAL4^sca-109-68

(Stern et al., 2007)

anterior dorsocentral bristle | adult stage, with Scer\GAL4^ap-md544

(Stern et al., 2009)

anterior dorsocentral bristle | adult stage, with Scer\GAL4^sca-109-68

(Stern et al., 2009)

anterior postalar bristle | adult stage, with Scer\GAL4^ap-md544

(Stern et al., 2009)

anterior postalar bristle | adult stage, with Scer\GAL4^sca-109-68

(Stern et al., 2009)

anterior scutellar bristle, with Scer\GAL4^ap-md544

(Stern et al., 2007)

anterior scutellar bristle, with Scer\GAL4^sca-109-68

(Stern et al., 2007)

anterior scutellar bristle | adult stage, with Scer\GAL4^ap-md544

(Stern et al., 2009)

anterior scutellar bristle | adult stage, with Scer\GAL4^sca-109-68

(Stern et al., 2009)

anterior supraalar bristle | adult stage, with Scer\GAL4^ap-md544

(Stern et al., 2009)

interommatidial bristle | increased number, with Scer\GAL4^GMR.PU

(Stern et al., 2007)

mesonotum, with Scer\GAL4^ap-md544

(Stern et al., 2007)

mesonotum, with Scer\GAL4^sca-109-68

(Stern et al., 2007)

mesonotum | adult stage, with Scer\GAL4^ap-md544

(Stern et al., 2009)

mesonotum | adult stage, with Scer\GAL4^sca-109-68

(Stern et al., 2009)

notal microchaeta | adult stage, with Scer\GAL4^ap-md544

(Stern et al., 2009)

posterior dorsocentral bristle, with Scer\GAL4^ap-md544

(Stern et al., 2007)

posterior dorsocentral bristle, with Scer\GAL4^sca-109-68

(Stern et al., 2007)

posterior dorsocentral bristle | adult stage, with Scer\GAL4^ap-md544

(Stern et al., 2009)

posterior notopleural bristle | adult stage, with Scer\GAL4^ap-md544

(Stern et al., 2009)

posterior postalar bristle | adult stage, with Scer\GAL4^ap-md544

(Stern et al., 2009)

posterior scutellar bristle, with Scer\GAL4^ap-md544

(Stern et al., 2007)

posterior scutellar bristle, with Scer\GAL4^sca-109-68

(Stern et al., 2007)

posterior scutellar bristle | adult stage, with Scer\GAL4^ap-md544

(Stern et al., 2009)

posterior supraalar bristle | adult stage, with Scer\GAL4^ap-md544

(Stern et al., 2009)

posterior supraalar bristle | adult stage, with Scer\GAL4^sca-109-68

(Stern et al., 2009)

presutural bristle | adult stage, with Scer\GAL4^ap-md544

(Stern et al., 2009)

scutellum | adult stage, with Scer\GAL4^ap-md544

(Stern et al., 2009)

tormogen cell, with Scer\GAL4^ap-md544

(Stern et al., 2007)

tormogen cell, with Scer\GAL4^sca-109-68

(Stern et al., 2007)

wing vein | ectopic, with Scer\GAL4^69B

(Stern et al., 2007)

wing vein | ectopic, with Scer\GAL4^Bx-MS1096

(Stern et al., 2007)

wing vein | ectopic, with Scer\GAL4^C-765

(Stern et al., 2007)

wing vein | ectopic, with Scer\GAL4^en.PU

(Stern et al., 2007)

Detailed Description

Statement

Reference

Scer\GAL4^ap-md544-mediated expression of CtBP^Scer\UAS.cSa induces bald phenotype for all thoracic sensory bristles but the anterior notopleural bristle. In addition, reductions in the numbers of microchaetes and the occasional malformation of scutellar cuticle are observed.

Scer\GAL4^sca-109-68-mediated expression of CtBP^Scer\UAS.cSa disrupts the anterior scutellar bristle, anterior dorsocentral bristle, anterior postalar bristle and posterior supraalar bristles and their sockets - a bald phenotype results.

(Stern et al., 2009)

Overexpression of CtBP^Scer\UAS.cSa using Scer\GAL4^GMR.PU induces extra ommatidial eye bristles.

Overexpression of CtBP^Scer\UAS.cSa using Scer\GAL4^C-765, Scer\GAL4^69B, Scer\GAL4^en.PU or Scer\GAL4^Bx-MS1096 induces ectopic veins in the wing.

Overexpression of CtBP^Scer\UAS.cSa using Scer\GAL4^ap-md544 or Scer\GAL4^sca-109-68 causes loss of macrochaetes and their sockets, and occasional malformation of cuticle in the dorsal thorax.

(Stern et al., 2007)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

CtBP^UAS.cSa, Scer\GAL4^ap-md544 has posterior scutellar bristle | adult stage phenotype, suppressible | partially by ush[+]/ush²

(Stern et al., 2009)

CtBP^UAS.cSa, Scer\GAL4^ap-md544 has anterior scutellar bristle | adult stage phenotype, suppressible | partially by ush[+]/ush²

(Stern et al., 2009)

CtBP^UAS.cSa, Scer\GAL4^ap-md544 has posterior dorsocentral bristle | adult stage phenotype, suppressible | partially by ush[+]/ush²

(Stern et al., 2009)

CtBP^UAS.cSa, Scer\GAL4^ap-md544 has anterior dorsocentral bristle | adult stage phenotype, suppressible | partially by ush[+]/ush²

(Stern et al., 2009)

CtBP^UAS.cSa, Scer\GAL4^ap-md544 has posterior scutellar bristle | adult stage phenotype, suppressible | partially by pnr[+]/pnr^VX6

(Stern et al., 2009)

CtBP^UAS.cSa, Scer\GAL4^ap-md544 has anterior scutellar bristle | adult stage phenotype, suppressible | partially by pnr[+]/pnr^VX6

(Stern et al., 2009)

CtBP^UAS.cSa, Scer\GAL4^ap-md544 has posterior dorsocentral bristle | adult stage phenotype, suppressible | partially by pnr[+]/pnr^VX6

(Stern et al., 2009)

CtBP^UAS.cSa, Scer\GAL4^ap-md544 has anterior dorsocentral bristle | adult stage phenotype, suppressible | partially by pnr[+]/pnr^VX6

(Stern et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

ush²/+ or pnr^VX6/+ dominantly suppresses the missing thoracic bristle phenotype of CtBP^Scer\UAS.cSa, Scer\GAL4^ap-md544 flies.

(Stern et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CtBP^Scer\UAS.cSa

CtBP^UAS.cSa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Stern

Secondary FlyBase IDs

References (2)

Report Sections