FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Hsap\SNCAS129D.UAS
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General Information
Symbol
Hsap\SNCAS129D.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0281840
Feature type
allele
Associated gene
Hsap\SNCA
Associated Insertion(s)
Carried in Construct
P{UAS-Hsap\SNCA.S129D}
Key Links
Transgenic product class
missense_variant
(Chen and Feany, 2005)
polypeptide_post_translational_processing_variant
(Chen and Feany, 2005)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Chen and Feany, 2005)
polypeptide_post_translational_processing_variant
(Chen and Feany, 2005)
Mutagen
in vitro construct
(Chen and Feany, 2005)
Progenitor genotype
Carried in construct
P{UAS-Hsap\SNCA.S129D}
Cytology
Description

UASt regulatory sequences drive expression of Hsap\SNCA mutated to carry an S129D amino acid replacement (phosphomimetic mutation).

(Chen and Feany, 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\SNCA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  synucleinopathy
      CEA
      (Chen et al., 2009)
      model of  Parkinson's disease
      CEA
      (Chen and Feany, 2005)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  synucleinopathy
      is ameliorated by SharkUAS.cFa
      (Chen et al., 2009)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In 10-day and 20-day old flies expressing Hsap\SNCAS129D.Scer\UAS under the control of Scer\GAL4elav.PU, the number of dopaminergic neurons in the dorsomedial clusters is significantly reduced compared to controls.

      Scer\GAL4GMR.PU-mediated expression of Hsap\SNCAS129D.Scer\UAS causes prominent retinal degeneration.

      (Chen et al., 2009)

      1 day old flies expressing Hsap\SNCAS129D.Scer\UAS under the control of Scer\GAL4elav.PU have a normal number of dorsomedial dopaminergic neurons, while 10 day old flies show a substantial loss of these neurons compared to wild type. No significant loss of neurons in the cortex or attenuation of neuropil is seen.

      Adults expressing Hsap\SNCAS129D.Scer\UAS under the control of Scer\GAL4GMR.PF have prominent retinal degeneration with substantial loss of photoreceptors and support cells. Marked cell loss is seen by 10 days.

      (Chen and Feany, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Coexpression of sharkScer\UAS.cFa significantly rescues the neurotoxicity of Scer\GAL4elav.PU-mediated Hsap\SNCAS129D.Scer\UAS expression.

      Coexpression of sharkScer\UAS.cFa attenuates the retinal degeneration caused by Scer\GAL4GMR.PU-mediated Hsap\SNCAS129D.Scer\UAS expression.

      (Chen et al., 2009)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\SNCAS129D.Scer\UAS
      Hsap\SNCAS129D.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)