FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\SNCAYF.UAS
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General Information
Symbol
Hsap\SNCAYF.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0281843
Feature type
allele
Associated gene
Hsap\SNCA
Associated Insertion(s)
Carried in Construct
P{UAS-αsyn.YF}
Key Links
Transgenic product class
missense_variant
(Chen et al., 2009)
polypeptide_post_translational_processing_variant
(Chen et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Chen et al., 2009)
polypeptide_post_translational_processing_variant
(Chen et al., 2009)
Mutagen
in vitro construct
(Chen et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-αsyn.YF}
Cytology
Description

UAS regulates expression of a Hsap\SNCA cDNA in which the COOH-terminal codons for Y125, Y133 and Y136 are replaced with codons for phenylalanine to prevent phosphorylation.

(Chen et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\SNCA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  synucleinopathy
      CEA
      (Chen et al., 2009)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In 1-day and 5-day old flies expressing Hsap\SNCAYF.Scer\UAS under the control of Scer\GAL4elav.PU, the number of dopaminergic neurons in the dorsomedial clusters is not significantly different from the number in controls. However, the number of such neurons in 10-day old flies is significantly reduced compared to controls, indicating accelerated onset of neurodegeneration. At 20 days, there is a marked loss of neurons. (Scer\GAL4elav.PU-mediated expression of Hsap\SNCAYF.Scer\UAS is not accompanied by widespread, general neurodegeneration in the brain.)

      Scer\GAL4GMR.PU-mediated expression of Hsap\SNCAYF.Scer\UAS causes prominent retinal degeneration, with vacuole formation and marked lossoloss of tissue integrity - the percentage of normal ommatidia is significantly decreased compared to controls.

      Flies expressing Hsap\SNCAYF.Scer\UAS under the control of Scer\GAL4elav.PU show a greater reduction in climbing ability with age, compared to controls.

      (Chen et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Phenotype Manifest In
      NOT suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Coexpression of sharkScer\UAS.cFa does not significantly rescue the neurotoxicity of Scer\GAL4elav.PU-mediated Hsap\SNCAYF.Scer\UAS expression.

      (Chen et al., 2009)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\SNCAYF.Scer\UAS
      Hsap\SNCAYF.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)