FlyBase Allele Report: Dmel\grnd[MI05292]

General Information

Symbol

Dmel\grnd^MI05292

Species

D. melanogaster

Name

FlyBase ID

FBal0281906

Feature type

allele

Associated gene

Dmel\grnd

Associated Insertion(s)

Mi{MIC}grnd^MI05292

Carried in Construct

Also Known As

grnd^Minos

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Andersen et al., 2015)

Mutagen

Progenitor genotype

Associated Insertion(s)

Mi{MIC}grnd^MI05292

Cytology

Description

Allele components

Component

Use(s)

Inserted element

Also carries

integrase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:18,485,543..18,485,543 [+]

(Poernbacher and Vincent, 2018, Muzzopappa et al., 2017, Bellen, 2013.1.29)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates high grade glioma

modeled by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, btl::Egfr^λ.UAS

(Portela et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage | progressive

(Muliyil et al., 2020)

decreased cell number | adult stage | progressive

(Muliyil et al., 2020)

viable

(Andersen et al., 2015)

Phenotype Manifest In

eye photoreceptor cell | decreased number

(Muliyil et al., 2020)

lipid droplet | adult stage | increased number

(Muliyil et al., 2020)

retina

(Muliyil et al., 2020)

Detailed Description

Statement

Reference

grnd^MI05292 homozygous retinas exhibit accumulation of lipid droplets in 1-day-old flies and retinal degeneration in 2-weeks-old flies when compared to controls.

(Muliyil et al., 2020)

grnd^MI05292 homozygotes do not show glial cell accumulation in the third instar larval brain, as compared to controls.

(Portela et al., 2019)

Homozygous flies are viable with no discernible phenotype.

(Andersen et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

grnd^MI05292/grnd^MI05292 is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

grnd^MI05292/grnd^MI05292 is a suppressor of neoplasia | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

grnd^MI05292 is a suppressor of increased cell death phenotype of Scer\GAL4^rn-GAL4-5, egr^UAS.cMa

(Andersen et al., 2015)

grnd^MI05292/Df(2L)BSC149 is a suppressor of increased cell death phenotype of Scer\GAL4^rn-GAL4-5, egr^UAS.cMa

(Andersen et al., 2015)

grnd^MI05292 is a suppressor of neoplasia phenotype of Scer\GAL4^rn-GAL4-5, crb^intra.UAS

(Andersen et al., 2015)

NOT Suppressor of

Statement

Reference

grnd^MI05292/grnd^MI05292 is a non-suppressor of neoplasia | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^hh.PU, dlg1^GD4689

(Muzzopappa et al., 2017)

grnd^MI05292/grnd^MI05292 is a non-suppressor of neoplasia | larval stage phenotype of BacA\p35^UAS.cHa, Scer\GAL4^hh.PU, rod^GD8768

(Muzzopappa et al., 2017)

Phenotype Manifest In

Suppressor of

Statement

Reference

grnd^MI05292/grnd^MI05292 is a suppressor of larval glial cell | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

grnd^MI05292/grnd^MI05292 is a suppressor of larval brain | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Portela et al., 2019)

NOT Suppressor of

Statement

Reference

grnd^MI05292/grnd^MI05292 is a non-suppressor of wing disc phenotype of Ras85D^V12.UAS, Scer\GAL4^hh.PU, dlg1^GD4689

(Muzzopappa et al., 2017)

grnd^MI05292/grnd^MI05292 is a non-suppressor of wing disc phenotype of BacA\p35^UAS.cHa, Scer\GAL4^hh.PU, rod^GD8768

(Muzzopappa et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

43677

y¹ w^*; Mi{MIC}grnd^MI05292

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

CG10176^MI05292

(Bellen, 2013.1.29)

Grnd^Minos

(Poernbacher and Vincent, 2018)

grnd^M

(Muzzopappa et al., 2017)

grnd^MI05292

(Muzzopappa et al., 2017)

grnd^Minos

(Muliyil et al., 2020, Andersen et al., 2015)

grndMINOS

(Portela et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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