FlyBase Allele Report: Dmel\slim[GS10238]

General Information

Symbol

Dmel\slim^GS10238

Species

D. melanogaster

Name

FlyBase ID

FBal0282322

Feature type

allele

Associated gene

Dmel\slim

Associated Insertion(s)

P{GSV6}slim^GS10238

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{GSV6}slim^GS10238

Cytology

Description

Insertion 508bp upstream of slim. The element is oriented such that the Scer\UAS regulatory elements in the P{GSV6} element drive overexpression of slim in a Scer\GAL4-dependent manner.

(Sekine et al., 2012)

Allele components

Component

Use(s)

Inserted element

P{GSV6}

misexpression element

Regulatory region(s)

UASt

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:18,440,449..18,440,449

(Sekine et al., 2012)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body color, with Scer\GAL4^pnr-MD237

(Sekine et al., 2012)

Phenotype Manifest In

adult cuticle, with Scer\GAL4^pnr-MD237

(Sekine et al., 2012)

Detailed Description

Statement

Reference

Expression of slim^GS10238 under the control of Scer\GAL4^pnr-MD237 results in an increase in melanisation of the adult thorax cuticle in the domain of Scer\GAL4^pnr-MD237 expression. This melanisation is suppressed by co=expression of slim^{dsRNA.Scer\UAS}.

(Sekine et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^pnr-MD237, slim^GS10238 has abnormal body color phenotype, enhanceable by Ask1^UAS.Tag:FLAG, Scer\GAL4^pnr-MD237

(Sekine et al., 2012)

Suppressed by

Statement

Reference

Scer\GAL4^pnr-MD237, slim^GS10238 has abnormal body color phenotype, suppressible | partially by Ask1^RNAi.UAS, Scer\GAL4^pnr-MD237

(Sekine et al., 2012)

Scer\GAL4^pnr-MD237, slim^GS10238 has abnormal body color phenotype, suppressible | partially by Scer\GAL4^pnr-MD237/p38a^DN.UAS

(Sekine et al., 2012)

Scer\GAL4^pnr-MD237, slim^GS10238 has abnormal body color phenotype, suppressible | partially by lic^GD7546/Scer\GAL4^pnr-MD237

(Sekine et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^pnr-MD237, slim^GS10238 has adult cuticle phenotype, enhanceable by Ask1^UAS.Tag:FLAG, Scer\GAL4^pnr-MD237

(Sekine et al., 2012)

Suppressed by

Statement

Reference

Scer\GAL4^pnr-MD237, slim^GS10238 has adult cuticle phenotype, suppressible | partially by Ask1^RNAi.UAS, Scer\GAL4^pnr-MD237

(Sekine et al., 2012)

Scer\GAL4^pnr-MD237, slim^GS10238 has adult cuticle phenotype, suppressible | partially by Scer\GAL4^pnr-MD237/p38a^DN.UAS

(Sekine et al., 2012)

Scer\GAL4^pnr-MD237, slim^GS10238 has adult cuticle phenotype, suppressible | partially by lic^GD7546/Scer\GAL4^pnr-MD237

(Sekine et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Pk92B^{Scer\UAS.T:Zzzz\FLAG} enhances the melanisation of the adult thorax cuticle seen in flies expressing slim^GS10238 under the control of Scer\GAL4^pnr-MD237.

Co-expression of either Pk92B^{dsRNA.Scer\UAS}, Mpk2^DN.Scer\UAS or lic^GD7546 partially suppresses the melanisation of the adult thorax cuticle seen in flies expressing slim^GS10238 under the control of Scer\GAL4^pnr-MD237.

(Sekine et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

kuma1

(Sekine et al., 2012)

slim^GS10238

Name Synonyms

key upswing in melanin accumulation 1

(Sekine et al., 2012)

Secondary FlyBase IDs

References (1)

Report Sections

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